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MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3056 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3003 | MetaboLights
ProteomicsProteomics analysis of human intestinal organoids during hypoxia and reoxygenation as a model to study ischemia-reperfusion injury
Intestinal ischemia-reperfusion (IR) injury is associated with high mortality rates, which have not improved in the past decades despite advanced insight in its pathophysiology using in vivo animal and human models. The inability to translate previous findings to effective therapies emphasizes the n...
ORGANISM(S): Homo sapiens (Human) 
2021-01-11 | PXD022999 | Pride
Intestinal organoids hypoxia-reoxygenation proteomics 
UnknownRTEF-1, an upstream gene of hypoxia-inducible factor-1α, accelerates recovery from ischemia.
Not available
S-EPMC3121413 | biostudies-literature
ProteomicsHypoxia induced sex-difference in zebrafish brain proteome profile reveals the crucial role of H3K9me3 in recovery from acute hypoxia
Understanding the molecular basis of sex differences in neural response to acute hypoxic insult has profound implications for the effective prevention and treatment of ischemic stroke. Global hypoxic-ischemic induced neural damage has been studied recently under the well-controlled, non-invasive, re...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-02-22 | PXD027528 | Pride
Ipa Sex difference Pathway analysis Itraq Hypoxia-ischemia recovery 
UnknownCerebral Oxygenation and Metabolism After Hypoxia-Ischemia.
Not available
S-EPMC9314655 | biostudies-literature
TranscriptomicsTranscriptional Response of Adult Mouse Brain to Hypoxia
Since normal brain function depends upon continuous oxygen delivery and short periods of hypoxia can precondition against subsequent ischemia, this study examined the effects of brief hypoxia on the whole genome transcriptional response in adult mouse brain. Genomic expression profiling was perfrome...
ORGANISM(S): Mus musculus 
2011-12-30 | E-GEOD-19709 | biostudies-arrayexpress
UnknownInduction of Mitochondrial Fragmentation and Mitophagy after Neonatal Hypoxia-Ischemia.
Not available
S-EPMC8997592 | biostudies-literature
UnknownTherapeutic hypothermia modulates the neurogenic response of the newborn piglet subventricular zone after hypoxia-ischemia.
Not available
S-EPMC10798892 | biostudies-literature
UnknownDevelopment-dependent regulation of molecular chaperones after hypoxia-ischemia.
Not available
S-EPMC4641006 | biostudies-literature
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