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TranscriptomicsTreatment of myeloma cell lines with the bromodomain inhibitor I-BET151
KMS12BM and H929 myeloma cells were treated in vitro with either I-BET151 1uM or vehicle (DMSO) for 6 hours (n=3 independent experiments for each cell line). Total RNA was extracted from H929 and KMS12BM cells using the RNeasy Mini kit (Qiagen). Genomic DNA contamination was eliminated using colum...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-MTAB-2122 | biostudies-arrayexpress
GenomicsBET inhibition in ovarian cancer (i-BET858, i-BET151)
BET inhibition in ovarian cancer (i-BET858, i-BET151)
PRJNA731034 | ENA
GenomicsBMDM treated with I-BET151 and sitmulated with IgG immune complex
BMDM treated with I-BET151 and sitmulated with IgG immune complex
PRJNA822764 | ENA
GenomicsBMDC treated with I-BET151 and sitmulated with IgG immune complex
BMDC treated with I-BET151 and sitmulated with IgG immune complex
PRJNA823712 | ENA
TranscriptomicsBET Protein Inhibition shows Efficacy Against JAK2V617F-Driven Neoplasms
Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of MLL-fusion protein driven leukemias. Here, we report that I-BET151, a highly specific BET family bromodomain inhibitor...
ORGANISM(S): Homo sapiens 
2013-08-20 | E-MTAB-1817 | biostudies-arrayexpress
TranscriptomicsInhibition of bromodomain and extra-terminal (BET) recruitment to chromatin as an effective treatment for mixed lineage leukaemia (MLL)-fusion leukaemia
Gene expression changes in MLL leukaemia following I-BET151 treatment. Note: Additional archives available (E-MTAB-774.additional.1.zip and E-MTAB-774.additional.2.zip) containing individual raw files. Select 'Browse all available files' to view.
ORGANISM(S): Homo sapiens 
2011-09-30 | E-MTAB-774 | biostudies-arrayexpress
GenomicsRNA sequencing analysis of wild-type and ITF2357 or I-BET151 or JQ1 treated mouse pancreatic cancer KPC cells
RNA sequencing analysis of wild-type and ITF2357 or I-BET151 or JQ1 treated mouse pancreatic cancer KPC cells
PRJNA894206 | ENA
TranscriptomicsBMDM treated with I-BET151 and sitmulated with IgG immune complex
Bone marrow derived macrophages were cultured and stimulated with I-BET151 or DMSO control, and stimulated with Ovalbumin-IgG immune complex or Ovalbumin control.
ORGANISM(S): Mus musculus 
2022-05-02 | GSE200033 | GEO
TranscriptomicsBMDC treated with I-BET151 and sitmulated with IgG immune complex
Bone marrow derived dendritic cells were cultured and stimulated with I-BET151 or DMSO control, and stimulated with Ovalbumin-IgG immune complex or Ovalbumin control.
ORGANISM(S): Mus musculus 
2022-05-02 | GSE200226 | GEO
GenomicsExpression DATA from E11.5 pancreatic buds treated with I-BET151 or JQ1 for 24h
Expression DATA from E11.5 pancreatic buds treated with I-BET151 or JQ1 for 24h
PRJNA432198 | ENA
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