Sort   by:  
 Page size 
TranscriptomicsGATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes in association with perturbations of developmental cell signaling pathways have been associated with PDAC development and progr...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-27173 | biostudies-arrayexpress
ProteomicsH.sapiens - Cell line, Pancreatic metastatic, SC (Kim,mcp,2014)
abundance based on Spectral counting, Pancreatic_metastatic, Interaction consistency score: 21.5, Coverage: 32
ORGANISM(S): 9606 
2014-00-00 | 4148541313 | PAXDB
GenomicsMSKCC Medical Donation Program Data Access Committee
Data Access Committee EGAC00001000588
EGAC00001000588 | EGA
TranscriptomicsGene expression changes in the intestinal crypts of mice with loss of imprinting
To identify genes differentially expressed in the intestinal crypts between LOI(+) and LOI(-) mice, we performed microarray experiments using RNA extracted from laser capture microdissection, by microdissecting an average of 8,000 crypts from each of 3 LOI(+) and 3 LOI(-) mice. Keywords: genetic mo...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8583 | biostudies-arrayexpress
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
GenomicsLarge-scale epigenetic reprogramming is punctuated late during the evolution of pancreatic cancer progression [ChIP-Seq]
During pancreatic cancer progression, heterogeneous subclonal populations evolve in the primary tumor that possess differing capacities to metastasize and cause patient death. However, the genetics of metastasis reflects that of the primary tumor, and PDAC driver mutations arise early. This raises t...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-63125 | biostudies-arrayexpress
GenomicsLarge-scale epigenetic reprogramming is punctuated late during the evolution of pancreatic cancer progression [BS-Seq]
During pancreatic cancer progression, heterogeneous subclonal populations evolve in the primary tumor that possess differing capacities to metastasize and cause patient death. However, the genetics of metastasis reflects that of the primary tumor, and PDAC driver mutations arise early. This raises t...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-63123 | biostudies-arrayexpress
TranscriptomicsLarge-scale epigenetic reprogramming is punctuated late during the evolution of pancreatic cancer progression [RNA-Seq]
During pancreatic cancer progression, heterogeneous subclonal populations evolve in the primary tumor that possess differing capacities to metastasize and cause patient death. However, the genetics of metastasis reflects that of the primary tumor, and PDAC driver mutations arise early. This raises t...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-63124 | biostudies-arrayexpress
GenomicsThe patterns and dynamics of genomic instability in metastatic pancreatic cancer
Pancreatic cancer is an aggressive malignancy with a five-year mortality of 97–98%, usually due to widespread metastatic disease. Previous studies indicate that this disease has a complex genomic landscape, with frequent copy number changes and point mutations, but genomic rearrangements have not ...
EGAS00000000064 | EGA
GenomicsSequencing of pancreatic cancer primary tumors and metastases
The extent of heterogeneity of driver gene mutations present in naturally occurring metastases is largely unknown, i.e. treatment-naïve metastatic disease. To address this issue, 60x whole genome sequencing of 26 metastases from 4 patients was carried out. We found that the identical driver gene m...
EGAS00001002186 | EGA
Sort   by:  
 Page size