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TranscriptomicsGene expression analysis of inducible ES cells overexpressing Etv2 (induced for 12 hours at day 3 of differentiation)
During embryogenesis, the endothelial and the hematopoietic lineages first appear during gastrulation in the blood island of the yolk sac. We have previously reported that an Ets variant gene 2 (Etv2/ER71) mutant embryo lacks hematopoietic and endothelial lineages, however, the precise roles of Etv2...
ORGANISM(S): Mus musculus 
2012-07-03 | E-GEOD-37658 | biostudies-arrayexpress
TranscriptomicsHoxA3 is an apical regulator of hemogenic endothelium
This SuperSeries is composed of the following subset Series: GSE25079: Epistasis analysis of Runx1 and Gata1 over HoxA3 in hemogenic endothelium GSE25080: Genes regulated by HoxA3 in endothelial and hematopoietic progenitors Refer to individual Series
ORGANISM(S): Mus musculus 
2010-12-20 | E-GEOD-25096 | biostudies-arrayexpress
GenomicsEmbryonic stem cell based system for the discovery and mapping of developmental transcriptional programs
Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) is the method of choice to study function of transcription factors in cell fate determination. This technique faces two major obstacles when applied to developmental studies: the availability of ChIP grade antibodies and access to ...
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-30882 | biostudies-arrayexpress
TranscriptomicsGene expression signatures for fractions of E7.5 whole embryos based on Endoglin and Flk-1 markers
Much remains unknown about the signals that induce early mesoderm to initiate hematopoietic differentiation. Here we show that endoglin (Eng), a receptor for the TGFβ superfamily, identifies all cells with hematopoietic fate in the early embryo. These arise in an Eng+Flk1+ mesodermal precursor popu...
ORGANISM(S): Mus musculus 
2012-04-22 | E-GEOD-37515 | biostudies-arrayexpress
TranscriptomicsNLRP7 promotes trophoblast lineage differentiation, YY1 binding and alters CpG methylation
Genome wide DNA methylation profiling of hESC in the untransduced, scrambled control and with knockdown of NLRP7 in undifferentiated and BMP4 differentiated states using the Illumina HumanMethylation 450 BeadChip. Several genomic sites exhibit altered methylation upon knocking down NLRP7. Bisulphite...
ORGANISM(S): Homo sapiens 
2013-11-04 | E-GEOD-45727 | biostudies-arrayexpress
Transcriptomics662 adult acute myeloid leukemia (AML) cases characterized on the Affymetrix Human Genome U133 Plus 2.0 Microarray
The pretreatment karyotype of leukemic blasts is currently the key determinant in therapy decision-making in acute myeloid leukemia (AML). However, approximately fifty percent of AML patients, often carrying a normal karyotype, are currently unclassifiable based these established methods. Gene expre...
ORGANISM(S): Homo sapiens 
2016-06-23 | E-MTAB-3444 | biostudies-arrayexpress
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