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TranscriptomicsNew molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-66429 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Danio rerio 
2016-02-15 | E-GEOD-51014 | biostudies-arrayexpress
TranscriptomicsNew molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach [Affymetrix]
Platelet reactivity (PR) in cardiovascular (CV) patients is variable between individuals and modulates clinical outcome. However, the determinants of platelet reactivity are largely unknown. Integration of data derived from high-throughput omics technologies may yield novel insights into the molecul...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-66426 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse bone marrow-derived macrophages (RNA-Seq)
Bone marrow (BM) cells were obtained by flushing the long bones of 8-week old C57BL/6 mice. BM cells were then were plated in macrophage SFM medium (Life Technologies) supplemented with penicillin-streptomycin and CSF-1 (Peprotech, 100 ng/ml) and cultured for one week to allow macrophage differenti...
ORGANISM(S): Mus musculus 
2014-11-01 | E-GEOD-58283 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Mus musculus 
2016-02-15 | E-GEOD-51012 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Danio rerio 
2016-02-18 | E-GEOD-51013 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Danio rerio 
2016-02-18 | E-GEOD-51018 | biostudies-arrayexpress
TranscriptomicsNew molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach [NanoString]
Platelet reactivity (PR) in cardiovascular (CV) patients is variable between individuals and modulates clinical outcome. However, the determinants of platelet reactivity are largely unknown. Integration of data derived from high-throughput omics technologies may yield novel insights into the molecul...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-66427 | biostudies-arrayexpress
TranscriptomicsLong RNA Seq on Sham vs MI Adult Mouse Heart
We systematically identified, annotated and characterised the mouse long non-coding transcriptome during myocardial infarction, revealing hundreds of novel heart specific lncRNAs with unique functional and regulatory characteristics. 2 conditions, 4 biological replicates per condition
ORGANISM(S): Mus musculus 
2014-05-06 | E-GEOD-52313 | biostudies-arrayexpress
GenomicsExtensive remodeling of DC function by rapid maturation-induced epigenetic gene silencing
Dendritic-cell (DC) maturation involves substantial remodeling of their gene-expression program. Most research has focused on inducible gene-expression networks promoting the acquisition of new functions, such as cytokine production and enhanced T-cell-stimulatory capacity. In contrast, mechanisms t...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-58864 | biostudies-arrayexpress
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