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MetabolomicsOmics and Computational Chemistry Reveal Environmental Residues of Anti-COVID-19 Drug Chloroquine Phosphate Drive Antibiotic Resistance Gene Dissemination
The widespread use of chloroquine phosphate (CQP) during the COVID-19 pandemic has led to its persistent residues in aquatic environments, yet its impact on the horizontal transfer of antibiotic resistance genes (ARGs) remains unknown. Herein, the effects and molecular mechanisms of CQP on plasmid-m...
2026-10-10 | MTBLS15990 | MetaboLights
MetabolomicsSystematic analyses of lipid mobilization by human lipid transfer proteins

Lipid transfer proteins (LTPs) maintain the specialised lipid compositions of biological membranes, and many are associated with disease. In eukaryotes, they support organellar functions by transporting lipids between compartmentalised metabolic pathways. However, for the majority of the hundreds...

2025-11-14 | MTBLS9567 | MetaboLights
ProteomicsIdentification of antibiotic resistance proteins via MiCId's augmented workflow. A mass spectrometry-based proteomics approach
Fast and accurate identification of pathogenic bacteria along with the identification of antibiotic resistance proteins is of paramount importance for the treatment of patients and public health. While mass spectrometry has become an important technique for these purposes there is a lack of mass spe...
ORGANISM(S): Pseudomonas aeruginosa Klebsiella pneumoniae Escherichia coli 
2022-06-09 | PXD026634 | Pride
Identification of antibiotic resistance proteins Bacteria identification Mass spectrometry 
MetabolomicsNonspecific activities of the major herbicide-resistance gene BAR
Bialaphos resistance (BAR) and phosphinothricin acetyltransferase (PAT) genes, which convey resistance to the broad-spectrum herbicide phosphinothricin (also known as glufosinate) via N-acetylation, have been globally used in basic plant research and genetically engineered crops. Although early in v...
2017-12-05 | MTBLS553 | MetaboLights
ProteomicsMechanisms of antibiotic resistance to enrofloxacin in uropathogenic Escherichia coli in dog
Escherichia coli (E. coli) urinary tract infections (UTIs) are becoming a serious problem both for pets and humans (zoonosis) due to the close contact and to the increasing resistance to antibiotics. Great progress has been made in the discovery of novel antibiotics to counteract E. coli pathogens. ...
ORGANISM(S): Escherichia coli 
2015-06-05 | PXD002000 | Pride
Escherichia coli Enrofloxacin Antibiotic resistance Urinary tract infections 
MetabolomicsCommon Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated ...
2019-08-19 | MTBLS678 | MetaboLights
UnknownIdentification of Antibiotic Resistance Proteins via MiCId's Augmented Workflow. A Mass Spectrometry-Based Proteomics Approach.
Not available
S-EPMC9164240 | biostudies-literature
MetabolomicsHfq Regulates Efflux Pump Expression and Purine Metabolic Pathway to Increase the Trimethoprim Resistance in Aeromonas veronii

Aeromonas veronii (A. veronii) is a zoonotic pathogen. It causes clinically a variety of diseases such as dysentery, bacteremia, and meningitis. And it also brings huge losses to aquaculture. A. veronii has been documented as a multiple antibiotic resistant bacterium. Hfq (host factor for RNA bac...

2020-02-19 | MTBLS1411 | MetaboLights
ProteomicsImpacts of resistance gene knock-outs on the proteome
The spread of antibiotic resistance has developed to all known antibiotics. Extended spectrum β-lactamase-producing bacteria are particularly problematic, as they are resistant to a wide range of commonly used antibiotics. Resistance to β-lactams is known to be multifactorial, although the underlyin...
ORGANISM(S): Escherichia coli 
2023-01-04 | PXD029140 | Pride
Escherichia coli Antibiotic resistance Β-lactamase Quantitative proteomics Tandem mass tag Lc-ms/ms 
ProteomicsProteomic network of antibiotic-induced outer membrane vesicles released by extensively drug-resistant Elizabethkingia anophelis
Elizabethkingia anophelis, antibiotic resistance, outer membrane vesicle, proteomics, protein-protein interaction.
ORGANISM(S): Elizabethkingia anophelis 
2022-07-11 | PXD033858 | Pride
Proteomics Protein-protein interaction Elizabethkingia anophelis Antibiotic resistance Outer membrane vesicle 
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