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GenomicsIKK-epsilon regulates the balance between the type I and type II interferon responses
Virus infection induces the production of type I and type II interferons (IFN-I and IFN-II), cytokines that mediate the antiviral response. IFN-I (IFN-a and -b) induces the assembly of ISGF3 (interferon-stimulated gene factor 3), a multimeric transcriptional activation complex comprised of STAT1, S...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-33913 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Atlantic salmon cell line SHK-1 exposed to interferon type 1 and interferon gamma for 6 or 24 hours
We have stimulated an Atlantic salmon cell line, SHK-1, with both type I and type II recombinant salmonid IFNs and analysed the transcriptional response by microarray analysis. Cells were exposed to recombinant IFNs for 6 or 24 h or were left unexposed as controls. RNA was hybridised to a 17k feat...
ORGANISM(S): Salmo salar 
2007-10-08 | E-MEXP-1023 | biostudies-arrayexpress
Genomics
IFN-I vs IFN-II transcriptome
PRJNA931836 | ENA
GenomicsIFN-γ-STAT1 Axis Drives MHC-II Antigen Presentation Potentiation in Tumor Associated Macrophages
IFN-γ-STAT1 Axis Drives MHC-II Antigen Presentation Potentiation in Tumor Associated Macrophages
PRJNA1246119 | ENA
TranscriptomicsTranscription profiling of human A549 cell line treated with type I and II interferons vs. controls
Type I and type II interferons (IFNs) bind to different cell surface receptors but activate overlapping signal transduction pathways. We examined the effects of a type I IFN (IFN-acon1) and a type II iFN (IFN-g1b) on gene experession in A549 cells and demonstrate that there is a common set of genes ...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-5542 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte-derived dendritic cells to study uptake of apoptotic cells by dendritic cells and induction of T-cell immunity
The identification of molecules for apoptotic cells (AC) uptake by dendritic cells (DCs) and induction of T cell immunity is a major challenge in immunology.
DCs generated from monocytes in the presence of IFN-alpha (IFN-alpha-DCs) are competent in taking up ACs and inducing a strong T cell immun...
ORGANISM(S): Homo sapiens 
2010-01-08 | E-MEXP-2000 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of IL-10 stimulated adherent peripheral blood mononuclear cells
The immune mechanisms that control resistance vs. susceptibility to mycobacterial infection in humans were investigated by studying leprosy skin lesions, the site where the battle between the host and the pathogen is joined. Using an integrative genomics approach, we found an inverse correlation be...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-43700 | biostudies-arrayexpress
TranscriptomicsStage-specific IFN-induced and IFN gene expression reveals convergence of type I and type II IFN and highlights their role in both acute and chronic phases of pathogenic SIV infection
Interferons (IFNs) play a major role in controlling viral infections including HIV/SIV infections. Persistent up-regulation of interferon stimulated genes (ISGs) is associated with chronic immune activation and progression in SIV/HIV infections, but the respective contribution of different IFNs is u...
ORGANISM(S): Macaca fascicularis 
2017-10-30 | E-MTAB-6068 | biostudies-arrayexpress
TranscriptomicsFiorentino 2006-7 dermatomyositis, lupus, control skin
Background: Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood. Methodology and Findings: We analyzed genome-wide expression data in DM skin and compared them to those from healthy controls....
ORGANISM(S): Homo sapiens 
2012-01-12 | E-GEOD-32245 | biostudies-arrayexpress
TranscriptomicsIFN-γ-STAT1 Axis Drives MHC-II Antigen Presentation Potentiation in Tumor Associated Macrophages
While the IFN-γ-STAT1 signaling pathway is well-characterized in promoting MHC class II (MHC-II)-dependent antigen presentation within pro-inflammatory macrophages during acute infections, its functional dynamics in tumor-associated macrophages (TAMs) remain poorly understood. Here, we systematicall...
ORGANISM(S): Mus musculus 
2026-02-22 | GSE293728 | GEO
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