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TranscriptomicsGene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms that Correlate with Worse Long-term Outcomes
Rationale: Interstitial fibrosis and tubular atrophy (IFTA) is found in ~25% of 1-year biopsies post-transplant(1, 2). It correlates with decreased graft survival when histological evidence of inflammation is present¬.(3-5) Identifying the etiology of IFTA is important because longterm graft surviva...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-76882 | biostudies-arrayexpress
UnknownThe WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.
Not available
S-EPMC1679672 | biostudies-literature
TranscriptomicsThe clinical and genomic significance of donor-specific antibody (DSA) positive/C4d negative and DSA negative/C4d negative transplant glomerulopathy
We investigated the clinical, histopathologic and genomic features of donor-specific antibody (DSA) +/C4d- and DSA-/C4d- transplant glomerulopathy (TGP) using microarrays. Comparison of the gene expression profiles of DSA-/C4d- TGP biopsies with ptc+g score > 1 to normal and IFTA (Interstitial Fibr...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-44131 | biostudies-arrayexpress
TranscriptomicsGene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms that Correlate with Worse Long-term Outcomes
Rationale: Interstitial fibrosis and tubular atrophy (IFTA) is found in ~25% of 1-year biopsies post-transplant(1, 2). It correlates with decreased graft survival when histological evidence of inflammation is present¬.(3-5) Identifying the etiology of IFTA is important because longterm graft surviva...
ORGANISM(S): Homo sapiens 
2016-01-15 | GSE76882 | GEO
TranscriptomicsGenomics of Chronic Rejection
We hypothesized that T cell-mediated immune mechanisms play a role in two conditions; 1: donor-specific antibody (DSA) negative transplant glomerulopathy (TGP) and 2: interstitial fibrosis and tubular atrophy (IFTA) with inflammation (i>0). We investigated gene expression profiles of those biopsies ...
ORGANISM(S): Homo sapiens 
2017-01-17 | GSE93658 | GEO
ProteomicsExtensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, referred to as anterograde and retrograde IFT “trains”. Anterograde trains deliver cargoes from the cell to the ciliary tip, then remodel into retrograde trains for cargo export. We set out to underst...
ORGANISM(S): Chlamydomonas Reinhardtii 
2024-08-21 | PXD049195 | JPOST Repository
ProteomicsExtensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport (Proteomics
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, referred to as anterograde and retrograde IFT “trains”. Anterograde trains deliver cargoes from the cell to the ciliary tip, then remodel into retrograde trains for cargo export. We set out to underst...
ORGANISM(S): Chlamydomonas Reinhardtii 
2024-08-21 | PXD049260 | JPOST Repository
TranscriptomicsBlood gene expression at 3 months post-transplantation predicts 1-year histologic features in renal transplantation
Histological analysis of biopsy is the gold standard to assess renal allograft status. Furthermore, 1-year protocol biopsy is often performed to evaluated graft outcome. However, since biopsy cannot be performed in a time serial basis, we decided to investigate whether blood can be a good compartmen...
ORGANISM(S): Homo sapiens 
2015-12-24 | E-GEOD-57731 | biostudies-arrayexpress
TranscriptomicsBlood gene expression at 3 months post-transplantation predicts 1-year histologic features in renal transplantation
Histological analysis of biopsy is the gold standard to assess renal allograft status. Furthermore, 1-year protocol biopsy is often performed to evaluated graft outcome. However, since biopsy cannot be performed in a time serial basis, we decided to investigate whether blood can be a good compartmen...
ORGANISM(S): Homo sapiens 
2015-12-24 | GSE57731 | GEO
UnknownIFTA Foci Density: An Unrecognized Highly Prognostic Measurement of Fibrosis in Kidney Transplant Biopsies.
Not available
S-EPMC11441796 | biostudies-literature
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