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TranscriptomicsGene expression change induced by bisphenol A in mouse urogenital sinus
Bisphenol A (BPA), an endocrine-disrupting chemical (EDC), is a well-known, ubiquitous estrogenic chemical. To investigate the effects of fetal exposure to low-dose BPA on the development of the prostate, we first examined the alterations of in situ sex steroid hormonal environment in the mouse urog...
ORGANISM(S): Mus musculus 
2010-12-06 | E-GEOD-24928 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ERa abalated differentiated osteoclasts
Estrogen clearly prevents osteoporotic bone loss by attenuating bone resorption. The molecular basis of how this is accomplished, however, remains elusive. Here we report a critical role of osteoclastic ERa in mediating estrogen action on bone in females. We selectively ablated ERa in differentiated...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7798 | biostudies-arrayexpress
TranscriptomicsVPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome
Rett syndrome (RTT) is a devastating neurodevelopmental disorder that occurs once in every 10,000-15,000 live female births. Despite intensive research, no effective cure is yet available. Valproic acid (VPA) has been used widely to treat mood disorder, epilepsy, and a growing number of other disord...
ORGANISM(S): Mus musculus 
2014-10-04 | E-GEOD-56780 | biostudies-arrayexpress
TranscriptomicsReduced adult neurogenesis and neuronal abnormalities in the hippocampus underlie cognitive deficiency following prenatal administration of the anti-epileptic drug valproic acid
Prenatal exposure to valproic acid, an established anti-epileptic drug, has been reported to impair postnatal cognitive function of children from epileptic mothers. Nevertheless, its pathology and proper treatment to minimize the effects remain unknown. In mice, we found that the postnatal cognitive...
ORGANISM(S): Mus musculus 
2015-12-08 | E-GEOD-42904 | biostudies-arrayexpress
TranscriptomicsExpression data from Dmp1-GFP sorted osteocytes
Estrogens are well known steroid hormones necessary to maintain bone health. In addition, mechanical loading, which estrogen signaling may intersect with the Wnt/β-catenin pathway, is also essential for bone health. As osteocytes are known as the major mechanosensory cells embedded in mineralized b...
ORGANISM(S): Mus musculus 
2013-12-12 | E-GEOD-41997 | biostudies-arrayexpress
TranscriptomicsIdentification of Myt1 as a subunit of the neural cell type-specific LSD1 complex
Regulation of spatiotemporal gene expression in higher eukaryotic cells is critical for the precise and orderly development of undifferentiated progenitors into committed cell types of the adult. Recently, dynamic epigenomic regulation, including chromatin remodeling and histone modifications by tra...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-49685 | biostudies-arrayexpress
TranscriptomicsExpression data from Xenopus embryos treated with TTNPB (RAR-agonist), AGN193109 (RAR-antagonist), or Control Vehicle
Percellome analysis of whole Xenopus embryos at developmental stage 18 Xenopus embryos were treated with TTNPB (RAR-agonist), AGN193109 (RAR-antagonist), or Control Vehicle at Nieuwkoop and Faber Stage 7. Embryos were collected at stage 18, followed by RNA extraction, hybridization on Affymetrix mi...
ORGANISM(S): Xenopus laevis 
2014-05-06 | E-GEOD-57352 | biostudies-arrayexpress
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