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TranscriptomicsExpression data from IgE+ and IgG1+ B lymphocytes in mice infected with Nippostrongylus brasiliensis
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE cells in these memory responses is particularly unclear. IgE B-cell differentiation is characterized by a transient GC phase, a bias towards the plasma cell (PC) ...
ORGANISM(S): Mus musculus 
2013-10-31 | E-GEOD-49033 | biostudies-arrayexpress
ProteomicsIgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells
In contrast to their clearly defined roles in allergic diseases, the physiologic functions of Immunoglobulin E antibodies (IgEs) and mast cells (MCs) remain enigmatic. Recent research supports the toxin hypothesis, showing that MCs and IgE-related type 2 immune responses can enhance host defense aga...
ORGANISM(S): Homo sapiens (Human) Apis mellifera (Honeybee) 
2021-11-25 | PXD023851 | Pride
Honeybee venom  host defense  ige  mast cells  toxin hypothesis 
ProteomicsIgE reactivity profiling in an asthma affected cohort
Background: Most asthmatic patients have high serum levels of IgE directed against common environmental allergens such as house dust mite, animal danders and moulds. However the presence of specific IgE against individual allergens alone does not account for asthma. Many individuals are atopic but n...
ORGANISM(S): Homo sapiens 
2012-01-03 | E-GEOD-20020 | biostudies-arrayexpress
ProteomicsProtein profiling of human serum against a panel of allergens.
Current diagnostics for allergies, such as skin prick and radioallergosorbent tests, do not allow for inexpensive, high-throughput screening of patients. Additionally, extracts used in these methods are made from washed pollen that lacks pollen surface materials that may contain allergens. We soug...
ORGANISM(S): Homo sapiens 
2010-09-08 | E-MTAB-177 | biostudies-arrayexpress
ProteomicsIgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus
Best known for their roles in allergic diseases, the physiologic function of immunoglobulin E (IgE) and mast cells (the so-called allergy module of immunity) has been enigmatic. Recent evidence shows that allergic reactions can help to protect against the toxicity of venoms. As bacteria are a potent...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-10 | PXD019107 | Pride
Human allergies Mast cells Ige antibodies Host defense Bacterial infection 
MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
GenomicsPeptide binding human IgE
Peptide binding to human IgE antibody
PRJEB87853 | ENA
GenomicsInduction of natural IgE by glucocorticoids
Induction of natural IgE by glucocorticoids
PRJNA841355 | ENA
TranscriptomicsTranscription profiling of mouse IgE/antigen-activated mast cells stimulated with TIM-3
TIM-3 is known to be expressed on dendritic cells, monocytes, melanoma cells, mast cells and on activated Th1 cells. In activated Th1 cells, stimulating TIM-3 by one of its ligands, galectin-9, leads to apoptosis and thus it plays a central role in terminating Th1-type immune responses. Interestingl...
ORGANISM(S): Mus musculus 
2009-10-15 | E-GEOD-14438 | biostudies-arrayexpress
UnknownAntibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.
Not available
S-EPMC2877936 | biostudies-literature
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