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ProteomicsTomosyn is upregulated by IgE and functions as a PKC-regulated fusion clamp in mast cell degranulation
The regulation of soluble N ethylmaleimide sensitive factor attachment receptor (SNARE) mediated membrane fusion by upstream signaling events is poorly understood. Here we show that the SNARE binding protein tomosyn-1 negatively regulates type I IgE Fc receptor (FcRI) induced degranulation of mast c...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-04 | PXD010047 | Pride
Q-exactive plus Immunoprepicipitations Mast cells Mouse Phosphorylations Ige fc receptor 
Genomics
Role of IgE-Fc Epsilon Receptor 1 in Pathological Cardiac Remodeling and Dysfunction
PRJNA554512 | ENA
GenomicsMolecular mechanism of IgE-mediated FcεRI activation
Molecular mechanism of IgE-mediated FcεRI activation
PRJNA1166917 | ENA
UnknownA soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum.
Not available
S-EPMC3081330 | biostudies-literature
TranscriptomicsMolecular mechanism of IgE-mediated FcεRI activation
The high-affinity Fc receptor for IgE, mainly present on mast cells and basophils, plays a crucial role in the development of allergic diseases. Monomeric IgE binding to receptor regulates mast cell survival, differentiation, and maturation. However, the underlying molecular mechanism remains unclea...
ORGANISM(S): Rattus norvegicus 
2024-11-30 | GSE278387 | GEO
UnknownMapping of the CD23 binding site on immunoglobulin E (IgE) and allosteric control of the IgE-Fc epsilonRI interaction.
Not available
S-EPMC3438978 | biostudies-literature
UnknownThe evolution of flexibility and function in the Fc domains of IgM, IgY, and IgE.
Not available
S-EPMC11496790 | biostudies-literature
UnknownA range of Cℇ3-Cℇ4 interdomain angles in IgE Fc accommodate binding to its receptor CD23.
Not available
S-EPMC3944690 | biostudies-literature
UnknownIgE binds asymmetrically to its B cell receptor CD23.
Not available
S-EPMC5374546 | biostudies-literature
UnknownMutations in an avian IgY-Fc fragment reveal the locations of monocyte Fc receptor binding sites.
Not available
S-EPMC2795851 | biostudies-literature
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