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TranscriptomicsHigh IGFBP2 Expression Correlates with Tumor Severity in Pediatric Rhabdomyosarcoma.
Rhabdomyosarcoma (RMS) is the most common childhood sarcoma and is identified as either the embryonal or alveolar (ARMS) subtype. In approximately 75% of cases, ARMSs are characterized by specific chromosomal translocations that involve PAX and FKHR genes. ARMS gene expression signatures vary, depen...
ORGANISM(S): Homo sapiens 
2011-12-05 | E-GEOD-23196 | biostudies-arrayexpress
ProteomicsIGFBP2 secretion by mammary adipocytes limits breast cancer invasion
The progression of noninvasive ductal carcinoma in situ to invasive ductal carcinoma for patients with breast cancer results in a significantly poorer prognosis and is the precursor to metastatic disease. In this work, we have identified insulin-like growth factor–binding protein 2 (IGFBP2) as a pot...
ORGANISM(S): Homo sapiens (Human) 
2023-07-13 | PXD036479 | Pride
Lc-msms Igfbp2 Gfp trap 
TranscriptomicsIGFBP2 driven glioma progression is prevented by blocking a clinically significant network of integrin, ILK, and NK-kB
Insulin-like growth factor-binding protein 2 (IGFBP2) is increasingly recognized as a glioma oncogene, emerging as a target for therapeutic intervention. In this study, we used an integrative approach to characterizing the IGFBP2 network, combining transcriptional profiling of human glioma with vali...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35467 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of breast cancer cells with Insulin like growth factor binding protein 2 (IGFBP2) knockdown
The study was carried out to identify the genes regulated upon IGFBP2 modulation in breast cancer. This will help to understand the molecular targets and biological pathways targeted by IGFBP2 in breast cancer. C5 (Cy5) Vs. Vector(Cy3), C5 (Cy5) Vs. Vector(Cy3), C12 (Cy5) Vs. Vector(Cy3), C12 (Cy5) ...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-40682 | biostudies-arrayexpress
GenomicsReduced levels of the hepatokine IGFBP2 associate with degree of NAFLD
Reduced levels of the hepatokine IGFBP2 associate with degree of NAFLD
PRJNA587498 | ENA
GenomicsGene expression profile of MDA-MB-468 cell line over-expressing IGFBP2 gene
Gene expression profile of MDA-MB-468 cell line over-expressing IGFBP2 gene
PRJNA949183 | ENA
GenomicsRedox-Dependent Igfbp2 Signaling Controls Brca1 DNA Damage Response to Govern Neural Stem Cell Fate
Redox-Dependent Igfbp2 Signaling Controls Brca1 DNA Damage Response to Govern Neural Stem Cell Fate
PRJNA916906 | ENA
TranscriptomicsHigh IGFBP2 Expression Correlates with Tumor Severity in Pediatric Rhabdomyosarcoma.
Rhabdomyosarcoma (RMS) is the most common childhood sarcoma and is identified as either the embryonal or alveolar (ARMS) subtype. In approximately 75% of cases, ARMSs are characterized by specific chromosomal translocations that involve PAX and FKHR genes. ARMS gene expression signatures vary, depen...
ORGANISM(S): Homo sapiens 
2011-12-05 | GSE23196 | GEO
TranscriptomicsReduced levels of the hepatokine IGFBP2 associate with degree of NAFLD
Background and aim: The Insulin-like growth factor (IGF) axis is increasingly suggested to be involved in fatty liver disease and progression. We identified IGFBP2 as transcriptional regulatory effect network in liver steatosis and conducted a translational approach of its role in liver pathology fr...
ORGANISM(S): Mus musculus 
2020-06-29 | GSE139901 | GEO
UnknownIGFBP2 potentiates nuclear EGFR-STAT3 signaling.
Not available
S-EPMC4615268 | biostudies-literature
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