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TranscriptomicsmRNA Expression Comparison Between Igfbp7-null and wild type mice at Lactation Day 3
Insulin like growth factor binding protein 7, Igfbp7, is a secreted protein that in addition to modulating insulin and insulin-like growth factor signaling, it acts as a tumor suppressor gene in breast and other cancers. To elucidate the role of Igfbp7 in regulating the proliferation and differentia...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-45118 | biostudies-arrayexpress
ProteomicsMulti-organ systems study reveals Igfbp7 as a suppressor of gluconeogenesis after gastric bypass surgery
Roux-en-Y gastric bypass (RYGB) surgery reduces weight in obese patients. A marked decrease in blood glucose levels occurs before weight loss; however, key molecules that improve glycemic profile remain largely unknown. We used the RYGB surgery model in diet-induced obese (DIO) mice to monitor the p...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-23 | PXD015276 | Pride
Diabetes Bariatric surgery Insulin-like growth factor binding protein 7 Metabolic syndrome Protein-protein interactions Obesity Proteomics Tandem mass tagging 
GenomicsKnockdown of IGFBP7 decreases FGF2 expression in GC.
Knockdown of IGFBP7 decreases FGF2 expression in GC.
PRJNA854942 | ENA
TranscriptomicsKnockdown of IGFBP7 decreases FGF2 expression in GC.
Our previous study reported that IGFBP7 plays a role in maintaining mRNA stability of oncogenic lncRNA UBE2CP3 by RNA-RNA interaction. Clinical cohort studies had implied an oncogenic role of IGFBP7 in GC. However, the molecular mechanism of IGFBP7 in driving gastric cancer (GC) progression remains ...
ORGANISM(S): Homo sapiens 
2022-07-08 | GSE207373 | GEO
TranscriptomicsInsulin-like Growth Factor Binding Protein-7 (IGFBP7) regulation in Hepatocellular Carcinoma
Insulin like growth factor binding protein-7 (IGFBP7) inhibits IGF signaling and functions as a potential tumor suppressor for hepatocellular carcinoma (HCC). We profiled genome-wide gene expression of Igfbp7 knockout (Igfbp7-/-) mouse to demonstrate the constitutive activation of IGF signaling and ...
ORGANISM(S): Mus musculus 
2019-08-01 | GSE85427 | GEO
TranscriptomicsmRNA Expression Comparison Between Igfbp7-null and wild type mice at Lactation Day 3
Insulin like growth factor binding protein 7, Igfbp7, is a secreted protein that in addition to modulating insulin and insulin-like growth factor signaling, it acts as a tumor suppressor gene in breast and other cancers. To elucidate the role of Igfbp7 in regulating the proliferation and differentia...
ORGANISM(S): Mus musculus 
2014-09-02 | GSE45118 | GEO
UnknownIGFBP7 Deletion Promotes Hepatocellular Carcinoma.
Not available
S-EPMC5894280 | biostudies-literature
Genomics
Global liver transcriptome assay of WT, Igfbp7 null mutant and Igfbp7 LOE animals
PRJNA1018104 | ENA
UnknownLong non-coding RNA IGFBP7-AS1 accelerates the odontogenic differentiation of stem cells from human exfoliated deciduous teeth by regulating IGFBP7 expression.
Not available
S-EPMC9515061 | biostudies-literature
UnknownStructural insight into CD93 recognition by IGFBP7.
Not available
S-EPMC12364601 | biostudies-literature
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