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TranscriptomicsDietary heme stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon (part 2)
The risk for colon cancer is associated with nutrition, especially high fat and low calcium diets high in red meat. Red meat contains the iron porphyrin pigment heme, which induces cytotoxicity of the colon contents and epithelial hyperproliferation. Using a mouse model, we showed that heme caused d...
ORGANISM(S): Mus musculus 
2011-10-01 | E-GEOD-27848 | biostudies-arrayexpress
TranscriptomicsDietary heme stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon (part 1)
The risk for colon cancer is associated with nutrition, especially with diets high in red meat. Red meat contains the iron porphyrin pigment heme, which induces cytotoxicity of the colon contents and epithelial hyperproliferation. Using a mouse model, we showed that heme caused damage to the colonic...
ORGANISM(S): Mus musculus 
2011-10-01 | E-GEOD-27847 | biostudies-arrayexpress
TranscriptomicsStructural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Small Intestine data]
By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...
ORGANISM(S): Mus musculus 
2012-09-03 | E-GEOD-39974 | biostudies-arrayexpress
TranscriptomicsStructural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Colon data]
By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...
ORGANISM(S): Mus musculus 
2012-09-03 | E-GEOD-39973 | biostudies-arrayexpress
TranscriptomicsDietary heme induces instantaneous oxidative stress but delayed cytotoxicity and compensatory hyperproliferation in mouse colon
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface epithelium by luminal cytotoxicity and reactive oxygen species. This surface injury is compensated by hyperproliferation and hyperplasia of crypt cells, which was induced by a...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-40671 | biostudies-arrayexpress
TranscriptomicsMicrobiota facilitates dietary heme-induced epithelial hyperproliferation and hyperplasia by breaking the mucus barrier
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-40670 | biostudies-arrayexpress
TranscriptomicsDietary heme alters microbiota and mucosa of mouse colon without functional changes in host-microbe cross-talk.
Colon cancer is a major cause of cancer deaths in Western countries and is associated with diets high in red meat. Heme, the iron-porphyrin pigment of red meat, induces cytotoxicity of gut contents which injures surface cells leading to compensatory hyperproliferation of crypt cells. This hyperproli...
ORGANISM(S): Mus musculus 
2012-12-19 | E-GEOD-40672 | biostudies-arrayexpress
TranscriptomicsDietary heme modulates microbiota and mucosa of mouse colon without significant host-microbe cross talk
Previously, we showed that dietary heme injured the colonic surface epithelium and induced hyperproliferation by changing the surface to crypt signaling. In this study we investigated whether bacteria play a role in this changed signaling. Dietary heme increased the Bacteroidetes and decreased the F...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-34253 | biostudies-arrayexpress
TranscriptomicsDietary heme mediated PPARM-NM-1 activation does not affect the heme-induced epithelial hyperproliferation and hyperplasia in mouse colon
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface epithelium by luminal cytotoxicity and reactive oxygen species. This surface injury is overcompensated by hyperproliferation and hyperplasia of crypt cells. Transcriptome anal...
ORGANISM(S): Mus musculus 
2012-08-22 | E-GEOD-37006 | biostudies-arrayexpress
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