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TranscriptomicsCompensatory IKKa activation of classical NF-kB signaling during IKKb inhibition
A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive NF-kB pathway signaling for survival. Small molecule inhibitors of IkB kinase b (IKKb), a key regulator of the NF-kB pathway, kill ABC DLBCL cells and hold promise for the treatment ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-11902 | biostudies-arrayexpress
TranscriptomicsExpression profile of WT and IKKb(EE)IEC epithelial cells (IEC)
To investigate NF-kB-driven gene expression in IEC, we performed microarray analysis from enterocytes of mice that express a constitutively active form of IKKb in intestinal epithelial cells Total RNA was prepared from enterocytes obtained from small intestines of IKKb(EE)IEC and WT littermates. Tw...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-29701 | biostudies-arrayexpress
GenomicsEffect of tubular IKKb deletion in acute ischemic kidney injury
Effect of tubular IKKb deletion in acute ischemic kidney injury
PRJNA855461 | ENA
UnknownBRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells.
Not available
S-EPMC5681404 | biostudies-literature
TranscriptomicsAnalysis of IKKb (Ird5) regulated genes in control and hemizygote IKKb (Ird5) null mutant adult flies after DCV (Drosophila C virus) infection
This DNA microarray analysis (agilent) help to identify candidate genes induced by DCV infection and regulated by IKKb (Ird5) in control (Df/+) and hemizygote IKKb (Ird5) null mutant (Dr/Ird5[1]) adult flies.
ORGANISM(S): Drosophila melanogaster 
2018-08-14 | GSE99043 | GEO
UnknownConditional ablation of Ikkb inhibits melanoma tumor development in mice.
Not available
S-EPMC2898608 | biostudies-literature
TranscriptomicsEffect of tubular IKKb deletion in acute ischemic kidney injury
To establish the role of Ikkb during acute kidney injury, we use a mouse line with a specific deletion of Ikkb in the renal tubular system and exposed them to ischemia/reperfusion. Sample collection were done 2 days and 14 days after ischemia/reperfusion.
ORGANISM(S): Mus musculus 
2022-07-09 | GSE207430 | GEO
TranscriptomicsCompensatory IKKa activation of classical NF-kB signaling during IKKb inhibition
A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive NF-kB pathway signaling for survival. Small molecule inhibitors of IkB kinase b (IKKb), a key regulator of the NF-kB pathway, kill ABC DLBCL cells and hold promise for the treatment ...
ORGANISM(S): Homo sapiens 
2009-06-01 | GSE11902 | GEO
TranscriptomicsBRCA1-mimetic compound NSC35446.HCl inhits IKKB expression by reducing estrogen receptor alpha occupancy in the IKKB promoter and inhibts NF-κB activity in anti-estrogen resitant human breast cells
We previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ER), mimic the ability of BRCA1 to inhibit ER activity (“BRCA1-mimetics”), and overcome antiestrogen resistance. One such compound, the hydrochloride salt of NSC35446 (“NSC35446.HCl”), als...
ORGANISM(S): Homo sapiens 
2017-07-21 | GSE101691 | GEO
TranscriptomicsExpression profile of WT and IKKb(EE)IEC epithelial cells (IEC)
To investigate NF-kB-driven gene expression in IEC, we performed microarray analysis from enterocytes of mice that express a constitutively active form of IKKb in intestinal epithelial cells
ORGANISM(S): Mus musculus 
2011-06-09 | GSE29701 | GEO
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