Il-16 - OmicsDI

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Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 (8)
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Streptomyces coelicolor A3(2) (4)

Organisms

Homo sapiens (130)
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Tachysurus fulvidraco x Tachysurus vachelli (1)
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Oryza sativa (1)
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feces metagenome (1)
mouse gut metagenome (1)

Repository

biostudies-arrayexpress (2047)
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pride (149)
geo (75)
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Squamous cell carcinoma has accession C0007137 in DiseaseStateDatabase NCI_Thesaurus (1)
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Infected (1)
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Exposed_Seronegative (1)
Head and neck squamous cell carcinoma (1)
Benign adenoma (1)
Mastitis (1)

Technology Type

Mass Spectrometry (151)
Shotgun proteomics (101)
Bottom-up proteomics (22)
Mass spectrometry (13)
Gel-based experiment (12)
Data-dependent acquisition (11)
Affinity purification coupled with mass spectrometry proteomics (9)
Data-independent acquisition (8)
Mass spectrometry assay (7)
SWATH MS (5)
Top-down proteomics (3)
NMR spectroscopy (2)
DiaPASEF (2)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
Other (1)
ESI (1)
PAcIFIC (1)
All-ion fragmentation (1)
SRM/MRM (1)

Instrument Platform

Illumina NovaSeq 6000 (49)
NextSeq 500 (49)
Illumina HiSeq 2500 (30)
Illumina HiSeq 2000 (25)
Illumina HiSeq 4000 (22)
NextSeq 2000 (10)
NextSeq 550 (9)
Illumina MiSeq (8)
GenePix 4000B [Axon Instruments] (6)
Illumina HiSeq 1500 (6)
GenePix Professional 4200A [Axon Instruments] (5)
Axon- GenePix4000B (5)
G2565BA DNA microarray scanner [Agilent] (5)
Illumina Genome Analyzer IIx (4)
Illumina Genome Analyzer II (4)
Illumina NovaSeq X (4)
Chemostat (3)
DELL PRECISION 7500 (2)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
MA900, Sony (2)
10x Chromium Controller (2)
Axon Instruments GenePix 4000B scanner (2)
AB 5500 Genetic Analyzer (2)
Illumina Genome Analyzer (2)
GeneChip Scanner 3000 [Affymetrix] (2)
BD GasPak 150 Jar (2)
GenePix 4000A [Axon Instruments] (2)
Generation III Scanner (2)
Variable Atmosphere Incubator (2)
NextSeq 1000 (2)

Publication Date

2013 (285)
2014 (223)
2015 (220)
2010 (204)
2012 (188)
2016 (156)
2011 (154)
2008 (103)
2009 (84)
2007 (71)
2021 (69)
2025 (66)
2022 (61)
2026 (58)
2023 (58)
2005 (54)
2019 (50)
2017 (50)
2018 (49)
2020 (43)
2024 (42)
2006 (37)
2004 (13)
2003 (3)

UNIPROT ID/AC

P60568 (2)
Q8WXI7 (1)
P14784 (1)
P31785 (1)
P13232 (1)

CHEBI ID

CHEBI:16856 (3)
CHEBI:18257 (3)
CHEBI:15428 (3)
CHEBI:16865 (3)
CHEBI:16196 (3)
CHEBI:17203 (3)
CHEBI:18211 (3)
CHEBI:15891 (3)
CHEBI:18050 (3)
CHEBI:15354 (3)
CHEBI:17368 (3)
CHEBI:171645 (2)
CHEBI:171614 (2)
CHEBI:171613 (2)
CHEBI:171430 (2)
CHEBI:137293 (2)
CHEBI:171114 (2)
CHEBI:171074 (2)
CHEBI:171040 (2)
CHEBI:171023 (2)
CHEBI:170998 (2)
CHEBI:170186 (2)
CHEBI:170907 (2)
CHEBI:170896 (2)
CHEBI:170692 (2)
CHEBI:170587 (2)
CHEBI:89528 (2)
CHEBI:170152 (2)
CHEBI:170150 (2)
CHEBI:73005 (2)

Metabolite Name

Pyroglutamic acid (3)
8-Aminooctanoic acid (3)
Choline (3)
Adenosine (3)
Spermidine (3)
PE-NMe(14:1(9Z)/14:1(9Z)) (2)
Rhoifolin (2)
O-phosphoethanolamine (2)
PA(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (2)
N-Acetyl-DL-tryptophan (2)
Testosterone glucuronide (2)
Behenic acid (2)
Tangeraxanthin (2)
PE-NMe(18:1(9Z)/18:1(9Z)) (2)
PE-NMe(16:0/16:0) (2)
Gamma-Caprolactone (2)
12-Methyltridecanoic acid (2)
Taurine (2)
Gamma-aminobutyric acid (2)
Isoleucine (2)
Glycine (2)
Sulfamethazine (2)
Spinosyn A (2)
Paraxanthine (2)
Fasciculic acid C (2)
L-Proline (2)
Ornithine (2)
7-Ketocholesterol (2)
2-Phenylglycine (2)
Phenylglyoxylic acid (2)

First Public Date

2014 (56)
2025 (38)
2024 (34)
2023 (29)
2022 (23)
2021 (22)
2026 (20)
2020 (18)
2019 (14)
2017 (11)
2015 (8)
2013 (7)
2018 (6)
2016 (4)

Modelling Approach

Ordinary differential equation model (3)

Lab affiliation

North Carolina State University (4)
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. (3)
Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany (3)
Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland (3)
Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München (3)
Tsinghua University Institute for Immunology (2)
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (2)
Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK (2)
The Gade Research Group for Infection and Immunity, Department of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway (2)
USDA-ARS (2)
Michigan State University (2)
Karolinska Institutet, Department of Medicine Solna, Unit of Translational Immunology (1)
National Center for Advancing Translational Sciences, National Institutes of Health, MD, USA (1)
Helmholtz Centre for Environmental Research - UFZ, Department of Molecular Systems Bioloy (1)
Bioinformatics Unit (MF 1), Department for Methods Development and Research Infrastructure, Robert Koch Institute, Berlin, Germany (1)
Proteomics Group-ProteoRed PRB3/ISCIII Instituto de Investigación Biomédica de A Coruña (INIBIC), Spain (1)
Laboratório de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. (1)
hubei academy of agricultural sciences (1)
Proteomics Group-ProteoRed PRB2/ISCIII Instituto de Investigación Biomédica de A Coruña (Spain) (1)
Institute of Biothermal Science and Technology, School of Medical Instruments and Food Engineering, University of Shanghai for Science and Technology (1)
Sanquin Research, Department of Plasma Proteins, Amsterdam, The Netherlands (1)
The University of Hong Kong, Department of Chemistry, Chemical Biology Centre and State Key Laboratory of Synthetic Chemistry (1)
McPhail Equine Performance Center, Department of Large Animal Clinical Sciences, Michigan State University (1)
Institute for Genomics, Biocomputing, and Biotechnology, Mississippi State University, Mississippi State, MS 39759, USA (1)
Sch1School of Pharmacy, Department of Chemistry,University of Wisconsin-Madison, Madison, Wisconsin, 53705, (1)
PRISM laboratory, Inserm U1192, University of Lille (1)
Cell Biology, Harvard Medical School, Boston, MA, USA (1)
Program in Molecular Medicine UMass Chan Medical School Worcester MA 01605 USA (1)
Epithelial Systems Biology Laboratory National Heart, Lung, and Blood Institute National Institutes of Health (1)
PPGEMN, School of Engineering, Mackenzie Presbyterian University & MackGraphe - Mackenzie Institute for Research in Graphene and Nanotechnologies, Mackenzie Presbyterian Institute, São Paulo – SP, 01302-907, Brazil (1)

IsPrivate

False (3)

Submitter Keywords

Immuno-oncology (2)

Modification

4-tetrahydrothiazine-3-carboxylic acid (1)
Not available (1)

Study type

Transcription profiling by array (1375)
RNA-seq of coding RNA (160)
ChIP-seq (142)
ChIP-chip by tiling array (72)
RNA-seq of coding RNA from single cells (37)
Unknown experiment type (29)
Methylation profiling by array (29)
Other (27)
Comparative genomic hybridization by array (26)
ChIP-chip by array (23)
Methylation profiling by high throughput sequencing (12)
Cell line - High-throughput sequencing (9)
Transcription profiling by RT-PCR (8)
MicroRNA profiling by array (8)
Proteomic profiling by array (8)
RNA-seq of non coding RNA (8)
High-throughput sequencing (6)
DNA-seq (6)
RNA-seq of total RNA (6)
Animal - High-throughput sequencing (4)
MicroRNA profiling by high throughput sequencing (4)
ATAC-seq (4)
Two-color microarray (3)
Transcription profiling by tiling array (3)
RNAi profiling by array (3)
Hi-C (3)
Transcription profiling by SAGE (2)
MNase-seq (2)
Animal - Single-cell sequencing (2)
Human - High-throughput sequencing (2)

Release Date

2013 (326)
2014 (298)
2021 (296)
2022 (295)
2015 (295)
2025 (291)
2023 (289)
2024 (235)
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2010 (226)
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2007 (77)
2026 (63)
2005 (60)
2006 (41)
2004 (14)
2003 (5)
1999 (3)
1997 (2)
2002 (1)
2001 (1)
2000 (1)
1998 (1)

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Mucosal-Associated-Invariant-T (MAIT) cells stimulated with IL-12/IL-12, anti-CD3/CD28 or both for 16 hours

Not available

ORGANISM(S): Homo sapiens

ST001653 | MetabolomicsWorkbench

IL-16 promotes anti-tumor immunity via establishing a Th1-dominant tumor microenvironment [RNA-seq]

PRJNA1039765 | ENA

Pyroptotic T-cell-derived active IL-16 has a driving function in endometriosis development

PRJNA955729 | ENA

IL-16 production is a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas

PRJNA1463852 | ENA

IL-16 promotes anti-tumor immunity via establishing a Th1-dominant tumor microenvironment [RNA-seq]

Overcoming immunosuppression in tumor microenvironment (TME) is fundamental to the development of novel cancer immunotherapies. Herein, we revealed an unrecognized role of IL-16 in shaping anti-tumor immunity. Compared with healthy subjects, cancer patients had impaired production of IL-16, which wa...

ORGANISM(S): Mus musculus

2025-01-20 | GSE247579 | GEO

The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression

PRJNA830480 | ENA

Pyroptotic T-cell-derived active IL-16 has a driving function in endometriosis development

Endometriosis is a common, chronic inflammatory condition that frequently results in pain and infertility and is estimated to affect 6–10% of women of reproductive age. However, the mechanisms underlying the induction of inflammation in endometriosis remain unclear. Here, we identified that ectopic ...

ORGANISM(S): Homo sapiens

2024-04-10 | GSE229735 | GEO

The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression II

PRJNA831866 | ENA

IL-16 production is a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas

Resistance to Bruton tyrosine kinase (BTK) inhibitors remains a major clinical challenge in B-cell lymphomas and often occurs without BTK or PLCG2 mutations. Here, we investigated non-genetic mechanisms of ibrutinib resistance in marginal zone lymphoma (MZL) and their broader therapeutic implication...

ORGANISM(S): Homo sapiens

2026-05-11 | GSE330451 | GEO

IL-17A influences essential functions of the monocyte / macrophage lineage and is involved in advanced murine and human atherosclerosis

Atherosclerosis is a chronic inflammatory disease. Lesion progression is primarily mediated by cells of the monocyte/macrophage lineage. Interleukin-17A is a pro-inflammatory cytokine, which modulates immune cell trafficking and is involved inflammation in (auto)immune and infectious diseases. But t...

ORGANISM(S): Homo sapiens

2014-10-01 | E-GEOD-60824 | biostudies-arrayexpress

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