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TranscriptomicsAdult Human Chondrocyte Response to IL-1B
IL-1B is an important cytokine that is often found to be up-regulated during osteoarthritic and rheumatoid joint diseases. It is viewed as a catabolic factor, inducing enzymes that allow for the degradation of the cartilage extracellular matrix and also has essential roles as an autocrine and parac...
ORGANISM(S): Homo sapiens 
2008-05-14 | E-GEOD-11427 | biostudies-arrayexpress
TranscriptomicsPdx1 overexpression sensitizes to IL-1b-induced apoptosis
Cytokines have been shown to play a key role in the destruction of beta cells. In the rat insulinoma cell line (INS-1ab) overexpressing pancreatic duodenum homeobox 1 (Pdx1) increases sensitivity to Interleukin 1b (IL-1b). To elucidate mechanisms of action underlying Pdx1 driven potentiation of beta...
ORGANISM(S): Rattus norvegicus 
2012-09-20 | E-GEOD-40642 | biostudies-arrayexpress
TranscriptomicsEffect of IL-1b treatment on cultured rat aortic smooth muscle cells
IL-1 plays an important role in atherosclerosis, and alters expression of a number of genes involved in atherosclerotic plaque development and progression. Smooth muscle cells play important roles in atherosclerotic plaque formation and stability, so this study was undertaken to determine the globa...
ORGANISM(S): Rattus norvegicus 
2012-12-31 | E-GEOD-21403 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts from wild type and IRAK-4 kinase dead animals stimulated with IL-1b for different durations to identify IRAK-4 kinase-dependent IL-1b response genes.
IRAK-4 is an essential component of the signal transduction complex downstream of the IL-1- and Toll-like receptors. Though regarded as the first kinase in the signaling cascade, the role of IRAK-4 kinase activity versus its scaffold function is still controversial. In order to investigate the role ...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6789 | biostudies-arrayexpress
GenomicsEffect of Dexamethasone, IL-1B and Dex+IL-1B on gene expression in Th17 cells
Effect of Dexamethasone, IL-1B and Dex+IL-1B on gene expression in Th17 cells
PRJNA961106 | ENA
TranscriptomicsProfiling whole lung from lung-specific IL-1b-Tg mice
This program aims at identifying the lung gene signature associated with inflammation and emphysema in IL-1b-Tg mouse COPD model to facilitate understanding of the disease mechanism and therapeutic compound testing The lung profiling data was analyzed by identifying genes that were up- and down-regu...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-38075 | biostudies-arrayexpress
GenomicsPLA2G2E is an inducer of IL-1B and CXCL2
PLA2G2E is an inducer of IL-1B and CXCL2
PRJNA1534888 | ENA
GenomicsEffect of IL-1b on primary human skin-relevant cells
Effect of IL-1b on primary human skin-relevant cells
PRJNA494529 | ENA
TranscriptomicsTranscription profiling of mouse IL-1b responses in receptor-reconstituted AcP-deficient neurons
The purpose was to determine AcP- and AcPb-dependent gene responses to IL-1 by virally-reconstituting AcP-deficient mouse embryonic cortical neurons with CD25 (control), full length AcP, AcPb or the combination of both. A control population was transduced with a CD25-expressing virus. Half the sampl...
ORGANISM(S): Mus musculus 
2009-07-12 | E-GEOD-16104 | biostudies-arrayexpress
GenomicsIL-1b+ tumor-associated macrophages fuel pathogenic inflammation in pancreatic cancer
IL-1b+ tumor-associated macrophages fuel pathogenic inflammation in pancreatic cancer
PRJNA901006 | ENA
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