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MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
ModelsIL-6 Signalling
The pro-inflammatory cytokines interleukin 1 (IL-1) and 6 (IL-6) are crucially involved in the regulation of a multitude of physiological processes, in particular coordinating the immune response upon bacterial infection and tissue injury. Both interleukins induce complex signalling cascades and tri...
2314 | Cell Collective
TranscriptomicsTime-series of IL-6 stimulated primary mouse hepatocytes
External stimulations of cells by hormones, growth factors or cytokines activate signal transduction pathways that subsequently induce a rearrangement of cellular gene expression. The representation and analysis of changes in the gene response is complicated, and essentially consists of multiple lay...
ORGANISM(S): Mus musculus 
2010-04-07 | E-GEOD-21031 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cholangiocarcinoma cells (cholangiocytes) expressing IL-6
The association between chronic inflammation and the development and progression of malignancy is exemplified in the biliary tract where persistent inflammation strongly predisposes to cholangiocarcinoma. The inflammatory cytokine interleukin-6 (IL-6) enhances tumor growth in cholangiocarcinoma by a...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-11883 | biostudies-arrayexpress
ModelsKessler2025 - IL-6 and IL-22 pathway in human hepatocytes
IL-6 and IL-22 pathway in human hepatocytes
2025-11-14 | MODEL2509100001 | BioModels
TranscriptomicsTranscription profiling of mouse bone marrow macrophages from IL-6-/- and IL-10-/- mutants treated with IL-10 or IL-6 stimulation in the presence of LPS
IL-10 or IL-6 stimulation of control 129xC57BL/6 murine bone marrow derived macrophages in the presence of LPS. We used microarrays to detail the global programme of gene expression changes in response to IL-6 or IL-10 stimulation in the presence of lipopolysaccharide. BMDMs were isolated from cont...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5589 | biostudies-arrayexpress
ModelsImmunological Model of sphingolipids with IL-6/IL-17/IL-23 in L. major infection
In diseased state, we demonstrated that increase in production of sphingosine-1-phosphate and overexpression of IL-6,lL-17 and IL-23 with SATB1 leads to disease progression.
2023-01-11 | MODEL2301110001 | BioModels
TranscriptomicsHigh weight differences between donor and recipient affect early kidney graft function -a role for IL-6 signaling
The frequency of delayed function of kidney transplants varies greatly and is associated with the quality of graft, donor age, and the duration of cold ischemia time. Body weight differences between donor and recipient can affect primary graft function. The underlying mechanism is poorly understood....
ORGANISM(S): Rattus norvegicus 
2010-04-08 | E-GEOD-15813 | biostudies-arrayexpress
ModelsImmunological Healthy State Model of Sphingolipids with IL-6/IL-17/IL-23 immune axis in L.major infection
In Healthy State, we demonstrated the controlled expression of sphingolipids and the controlled IL-6,IL-17,IL-23 cytokines signalling via SOCS3 mediated regulation.
2023-01-11 | MODEL2301110002 | BioModels
ModelsQi2013 - IL-6 and IFN crosstalk model
Qi2013 - IL-6 and IFN crosstalk model This model [BIOMD0000000544] describes the crosstalk between IFN-gamma and IL-6 induced signalling; it aims to outline mechanisms and factors that may control the interaction between both signalling pathways, discussing a role of heterodimer formation in signa...
2024-09-02 | BIOMD0000000544 | BioModels
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