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OtherEffects of IL2RA non-coding and coding sequence edits on IL2RA expression in primary human T cells.
We edited an intronic IL2RA enhancer or exon in primary human naïve T cells. Electroporated cells were activated and sorted on IL2RA expression over three days. Amplicon sequencing was used to assess the effects on sequence edits on IL2RA expression.
ORGANISM(S): Homo sapiens 
2017-07-30 | GSE88960 | GEO
UnknownDynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression.
Not available
S-EPMC6140818 | biostudies-literature
TranscriptomicsTranscriptome-wide analysis of IL2RA enhancer activation by CRISPRa
We previously performed a tiling CRISPR activation (CRISPRa) screen in Jurkat T cells to discover enhancers controlling IL2RA expression. This screen identified six regions where recruitment of dCas9-VP64 was sufficient to drive increased expression of IL2RA. We named these putative enhancers CRISPR...
ORGANISM(S): Homo sapiens 
2017-04-26 | GSE98177 | GEO
GenomicsNascent RNA-seq from in-vitro stimulated WT and Il2ra-deficient CD8 T cells
Nascent RNA-seq from in-vitro stimulated WT and Il2ra-deficient CD8 T cells
PRJNA910583 | ENA
UnknownThe type I diabetes association of the IL2RA locus.
Not available
S-EPMC2805446 | biostudies-literature
UnknownIL2RA is associated with persistence of rheumatoid arthritis.
Not available
S-EPMC4563834 | biostudies-literature
UnknownIL2RA is a prognostic indicator and correlated with immune characteristics of pancreatic ductal adenocarcinoma.
Not available
S-EPMC9592409 | biostudies-literature
UnknownCase Report: IL2RA (CD25) deficiency: first reported cases in Morocco.
Not available
S-EPMC12901503 | biostudies-literature
GenomicsHomo sapiens
Effects of IL2RA non-coding and coding sequence edits on IL2RA expression in primary human T cells.
PRJNA349190 | ENA
UnknownAssociation of the IL2RA/CD25 gene with juvenile idiopathic arthritis.
Not available
S-EPMC2963023 | biostudies-literature
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