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ProteomicsThe tumor suppressor SOCS1 diminishes tolerance to oxidative stress in hepatocellular carcinoma
SOCS1 is a tumor suppressor in hepatocellular carcinoma. Recently we showed that loss of SOCS1 in hepatocytes promotes NRF2 activation. Here we investigated how SOCS1 expression affected oxidative stress response in HCC cells. Murine Hepa1-6 cells expressing SOCS1 (Hepa-SOCS1) or control vector (Hep...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-22 | PXD047908 | Pride
Hepatocellular carcinoma  socs1  oxidative stress  cisplatin  tert-butyl hydroperoxide  mass spectrometry 
ProteomicsEssential role of NLRC5 in cancer immune surveillance and cancer immunoediting
Background/Objectives: Downregulation of NLRC5, the transcriptional activator of MHC class-I, results in tumor immune evasion via escape from CD8+ T cell-mediated tumor control. As NLRC5 deficiency does not abrogate CD8+ T cell development, we investigated whether NLRC5-dependent antitumor immune me...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-19 | PXD060523 | Pride
Cancer immune surveillance  cancer immunoediting  nlrc5  mhc class-i  3-methylcholanthrene  cytolytic t lymphocyte  granzyme 
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