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ProteomicsPro-inflammatory remodeling of high density lipoprotein (HDL) precedes development of dyslipidemia and hepatic steatosis upon exposure to four weeks of high fat diet
Long-term high fat feeding leads to hepatic steatosis, dyslipidemia, and a pro-inflammatory state. In a previous study, we observed this dysregulated metabolic phenotype when C57BL/6 mice were fed a high fat diet (HFD) for sixteen weeks. Additionally, a five-fold increase in liver gene expression of...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD010272 | Pride
High Inflammation Lipoprotien Liver Fat Steatosis Density Diet Plasma Dyslipidemia Hepatic 
ProteomicsDyslipidemia Alters HDL Metabolism and Function in NAFLD
Dyslipidemia and inflammation play key roles in the pathogenesis of both nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. NAFLD, particularly its severe form nonalcoholic steatohepatitis (NASH) is associated with increased cardiovascular disease (CVD) risk. HDL (high density lipoprotein...
ORGANISM(S): Homo sapiens (Human) 
2019-08-12 | PXD010199 | Pride
Ss Nonalcoholic Metabolism Nafld Steatosis Dyslipidemia Hepatic Simple Nash Inflammation Disease Cardiovascular Steatohepatitis 
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