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GenomicsTET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [MeDIP-Seq]
We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level i...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-44036 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Mycobacterium tuberculosis H37Rv in whole blood from HIV- and HIV+ individuals
Mycobacterium tuberculosis (M. tb), the cause of tuberculosis (TB), utilizes the blood circulation to spread systemically and establish infection, and the risk of developing active TB (pulmonary and extrapulmonary) is significantly increased in individuals infected with human immunodeficiency virus ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-03-31 | E-GEOD-49760 | biostudies-arrayexpress
TranscriptomicsTET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [RNA-seq]
We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level i...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-49833 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of tumor cells from the cerebrospinal fluid and matched primary tumors from metastatic breast cancer patients with leptomeningeal disease
We purified tumor cells in the CSF (M-bM-^@M-^\CSFTCM-bM-^@M-^]) from 15 metastatic breast cancer patients diagnosed with leptomeningeal disease using a two-step method involving immunomagnetic enrichment and fluorescence-activated cell sorting (IE/FACS). Magnetic beads coated with mAb to the epithe...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-46068 | biostudies-arrayexpress
Transcriptomicssingle-cell RNA sequencing of effector memory CD8+ T cells of nasal-associated lymphoid tissue (NALT), spleen, submandibular & cervical lymph nodes and blood of Epstein Barr Virus (EBV)-infected NSG mice engrafted with a human immune system (HIS mice)
To identify the difference in transcriptome of effector memory CD8+ T cells in different tissues of EBV-infected HIS mice, we sorted CD8+ CD62L- CD45RA- cells from NALT, spleen, lymph node and blood via flow cytometry-assisted sorting. We pooled the cells of three individual mice together in equal c...
ORGANISM(S): Homo sapiens 
2024-08-31 | E-MTAB-13853 | biostudies-arrayexpress
TranscriptomicsPersonal Omics Profiling Reveals Dynamic Molecular Phenotypes and Actionable Medical Risks
We have determined the whole genome sequence of an individual at high accuracy and performed an integrated analysis of omics profiles over a 1.5 year period that included healthy and two virally infected states. Omics profiling of transcriptomes, proteomes, cytokines, metabolomes and autoantibodyome...
ORGANISM(S): Homo sapiens 
2012-03-16 | E-GEOD-32874 | biostudies-arrayexpress
ProteomicsAutoantibody profile timecourse of UNK
We have determined the whole genome sequence of an individual at high accuracy and performed an integrated analysis of omics profiles over a 1.5 year period that included healthy and two virally infected states. Omics profiling of transcriptomes, proteomes, cytokines, metabolomes and autoantibodyome...
ORGANISM(S): Homo sapiens 
2012-03-16 | E-GEOD-32691 | biostudies-arrayexpress
Proteomics,MultiomicsHS_iPOP_PBMC2011_SecondBatch_81213151614_r01
HS_iPOP_PBMC2011_SecondBatch_81213151614_r01
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe003751 | PeptideAtlas
Proteomics,MultiomicsHS_iPOP_PBMC2011_SecondBatch_81213151614_r02
HS_iPOP_PBMC2011_SecondBatch_81213151614_r02
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe003771 | PeptideAtlas
Proteomics,MultiomicsHS_iPOP_PBMC2011_FirstBatch_r3
HS_iPOP_PBMC2011_FirstBatch_r3
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe003769 | PeptideAtlas
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