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ProteomicsXenogeneic-free culture of human intestinal stem cells on functional polymer-coated substrates for scalable, clinical-grade stem cell therapy
Inevitable need for basement membrane extract (BME) with undefined constituents, such as Matrigel, for intestinal stem cell (ISC) culture in traditional system poses a significant barrier that must be overcome for the development of clinical-grade, scalable, ready-to-use ISCs. Here, we propose a fun...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD050747 | Pride
Intestinal tissue repair Intestinal stem cell derived from 3d human intestinal organoids (isc3d-hio) Stock banking system Xenogeneic-free culture Functional polymer coating 
ProteomicsTailoring Polymer Surface for Long-term Reliable Xenogeneic-free Culture of Intestinal Stem Cells via Regulated Dynamic Migratory Behavior
Regenerative therapy employing intestinal stem cells (ISCs) holds a great promise for reliable epithelial restoration. However, achieving this goal requires scalable and robust, but fully defined culture platforms that eliminate the use of xenogeneic components while preserving stem cell function. M...
ORGANISM(S): Homo sapiens (Human) 
2025-07-07 | PXD064449 | Pride
Biomaterials Intestinal stem cells Plasma-treated polymers Cytoskeletal dynamics Surface engineering Regenerative medicine 
UnknownRising rural body-mass index is the main driver of the global obesity epidemic in adults.
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S-EPMC6784868 | biostudies-literature
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