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The inner membrane domain (IMD) is a metabolically active and laterally discrete membrane domain initially discovered in Mycobacterium smegmatis that correlates both temporally and spatially with polar cell envelope elongation. While it has remained unclear whether a similar membrane domain exists i...
ORGANISM(S): Mycobacterium tuberculosis TBR27 
2025-11-21 | PXD069609 | Pride
Strains from routine IMD surveillance Belgium
The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate NF-kB family members. We have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct fr...
ORGANISM(S): Drosophila melanogaster 
Effect of IMD-0354 on gene expression in melanoma A375 cells
Expression data from D. melanogaster guts with suppression of Imd in progenitors or enterocytes
Viral infection in Drosophila triggers inducible gene expression, but the function of many of these genes and the biological significance of their induction remain poorly understood. Here, we report the functional characterization of the gene Diedel, which is strongly induced following some viral in...
ORGANISM(S): Drosophila melanogaster 
Expression data from D. melanogaster intestinal stem cell with suppression of Imd in progenitors
We used RNA-seq to examine transcriptional proflies of midguts with suppression of Imd in progenitors (e_* samples) or enterocytes (M_* samples) . We found significant differences between the contributions of enterocyte IMD and progenitor IMD to intestinal homeostasis.
ORGANISM(S): Drosophila melanogaster 
2019-08-01 | GSE135154 | GEO
The purpose of this RNAseq is to analyse the effect of compound IMD-0354 on gene expression in melanoma A375 cells. RNAseq analysis identified unfolded protein response, cell cycle and DNA damage pathways to be effected by IMD-0354.
ORGANISM(S): Homo sapiens 
2021-02-02 | GSE165899 | GEO
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