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MetabolomicsCroquemort elicits activation of the immune deficiency pathway in ticks
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain e...
2023-04-27 | MTBLS686 | MetaboLights
TranscriptomicsTranscription profiling of Drosophila infected with Drosophila C virus reveals a third evolutionary conserved innate immunity pathway operates in drosophila and counters viral infection
The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate NF-kB family members. We have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct fr...
ORGANISM(S): Drosophila melanogaster 
2007-07-07 | E-GEOD-2828 | biostudies-arrayexpress
TranscriptomicsBacteria- and IMD Pathway-Independent Immune Defenses against Plasmodium falciparum in Anopheles gambiae
The mosquito Anopheles gambiae uses its innate immune system to control bacterial and Plasmodium infection of its midgut tissue. The activation of potent IMD pathway-mediated anti-Plasmodium falciparum defenses is dependent on the presence of the midgut microbiota, which activate this defense system...
ORGANISM(S): Anopheles gambiae 
2013-08-10 | E-GEOD-49690 | biostudies-arrayexpress
UnknownDrosophila Myc restores immune homeostasis of Imd pathway via activating miR-277 to inhibit imd/Tab2.
Not available
S-EPMC7455005 | biostudies-literature
TranscriptomicsThe cytokine DIEDEL and a viral homologue suppress deleterious IMD-dependent gene expression in drosophila
Viral infection in Drosophila triggers inducible gene expression, but the function of many of these genes and the biological significance of their induction remain poorly understood. Here, we report the functional characterization of the gene Diedel, which is strongly induced following some viral in...
ORGANISM(S): Drosophila melanogaster 
2016-01-07 | E-GEOD-68174 | biostudies-arrayexpress
UnknownMicrobiota activates IMD pathway and limits Sindbis infection in Aedes aegypti.
Not available
S-EPMC5324288 | biostudies-literature
UnknownAnopheles Imd pathway factors and effectors in infection intensity-dependent anti-Plasmodium action.
Not available
S-EPMC3369948 | biostudies-literature
UnknownVerloren negatively regulates the expression of IMD pathway dependent antimicrobial peptides in Drosophila.
Not available
S-EPMC8324896 | biostudies-literature
UnknownRudra interrupts receptor signaling complexes to negatively regulate the IMD pathway.
Not available
S-EPMC2483946 | biostudies-literature
UnknownInhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway.
Not available
S-EPMC1276168 | biostudies-literature
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