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UnknownValidation of Induced Microglia-Like Cells (iMG Cells) for Future Studies of Brain Diseases.
Not available
S-EPMC8063054 | biostudies-literature
UnknownAngiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease.
Not available
S-EPMC10491754 | biostudies-literature
UnknownCharacterization of IMG Microglial Cell Line as a Valuable In Vitro Tool for NLRP3 Inflammasome Studies.
Not available
S-EPMC11412188 | biostudies-literature
TranscriptomicsAn integrated toolkit for human microglia functional genomics
Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation protocols face challenges, such as prolonged diffe...
ORGANISM(S): Homo sapiens 
2024-04-17 | GSE244653 | GEO
TranscriptomicsGeneration and characterization of iPSC derived microglia from blood derived PBMCs for in vitro modeling of stimuli-specific neuroimmune responses
Microglia are highly specialized brain immune cells which express several genes known to influence the risk of developing Alzheimer’s disease. While interest in harnessing the potential neuroprotective functions of microglia using targeted therapeutics is high, it remains challenging to test emergin...
ORGANISM(S): Homo sapiens 
2025-09-02 | GSE306820 | GEO
UnknownThe RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia.
Not available
S-EPMC10216802 | biostudies-literature
TranscriptomicsHuman iPSC-derived microglia are genetically relevant to Alzheimer’s disease
Microglia is a primary brain immune cell type that has been implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD) and neurodevelopmental disorders such as schizophrenia. Generating microglia from human induced pluripotent stem cells (hiPSC) has become an attr...
ORGANISM(S): Homo sapiens 
2020-05-14 | GSE129630 | GEO
UnknownRetinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs.
Not available
S-EPMC11472886 | biostudies-literature
TranscriptomicsCannabinoid Receptor 2 Agonists Attenuate HIV Replication and Inflammatory Activation in HIV-infected Myeloid Cells
Emerging evidence suggests brain-resident myeloid cells, including macrophages and microglia, provide a reservoir for HIV infection in the central nervous system (CNS), and their inflammatory activation is a proposed pathogenic mechanism in HIV-associated neurocognitive disorders (HAND). We investig...
ORGANISM(S): Homo sapiens 
2025-01-22 | GSE250616 | GEO
UnknownDirect induction of ramified microglia-like cells from human monocytes: dynamic microglial dysfunction in Nasu-Hakola disease.
Not available
S-EPMC4019954 | biostudies-literature
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