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MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
TranscriptomicsWhole-genome expression analysis of immortalized murine E10.5 anterior and posterior limb cell lines
The transcriptomes of immortalized anterior and posterior limb cell lines derived from E10.5 embryos were compared. Total RNA extracted from three E10.5 anterior and posterior limb cell line samples were compared.
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-38370 | biostudies-arrayexpress
TranscriptomicsMolecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression - WES
Retaining the mutational pattern of tumors, immortalized cell lines represent excellent tools for the molecular study of genetic aberrations. Tumors can consist of subclones which develop under selective forces driven by mutational alterations. This explains why after therapy, relapsed clones can be...
ORGANISM(S): Homo sapiens 
2021-12-02 | E-MTAB-11039 | biostudies-arrayexpress
TranscriptomicsMolecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression - RNA-seq
Retaining the mutational pattern of tumors, immortalized cell lines represent excellent tools for the molecular study of genetic aberrations. Tumors can consist of subclones which develop under selective forces driven by mutational alterations. This explains why after therapy, relapsed clones can be...
ORGANISM(S): Homo sapiens 
2021-12-02 | E-MTAB-11038 | biostudies-arrayexpress
TranscriptomicsClonal Immortalized Human Glial Cell Lines Support Varying Levels of JC Virus Infection due to Differences in Cellular Gene Expression
JC virus (JCV) is a ubiquitous human polyomavirus that causes the demyelinating disease Progressive Multifocal Leukoencephalopathy (PML). JCV replicates in limited cell types in culture, predominantly in human glial cells. Thus, productive JCV infection is an indicator of the host cell transcription...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-GEOD-45639 | biostudies-arrayexpress
MetabolomicsCell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
GenomicsBasal transcriptomic profiling of immortalized cholangiocyte and breast cancer cell lines.
Basal transcriptomic profiling of immortalized cholangiocyte and breast cancer cell lines.
PRJNA515002 | ENA
TranscriptomicsA novel unusual chromosome 11 abnormality: a homozygous somatic deletion of the entire WT1 gene within a heterozygous 11p13 deletion and UPD limited to 11p15 in a Wilms tumor and establishment of an immortalized cell line
We describe a stromal predominant Wilms tumor with a complex, tumor specific chromosome 11 aberration: a homozygous deletion of the entire WT1 gene within a heterozygous 11p13 deletion and an additional region of uniparental disomy (UPD) limited to 11p15.5-p15.2 including the IGF2 gene. The tumor ca...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-71265 | biostudies-arrayexpress
ProteomicsTriple SILAC glycoproteomic analysis of NSCLC cell lines
Protein glycosylation plays a fundamental role in a multitude of biological processes, and the associated aberrant expression of glycoproteins in cancer has made them attractive targets as biomarkers and therapeutic targets. In this study, we examined differentially expressed glycoproteins in cell l...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-10 | MSV000079569 | MassIVE
TranscriptomicsThe LL-100 panel: 100 DSMZ cell lines for blood cancer studies; RNA-Seq
For many years, immortalized cell lines have been used as model systems for cancer research. Cell line panels were established for basic research and drug development, but did not cover the full spectrum of leukemia and lymphoma. Therefore, we now developed a novel panel (LL-100), 100 cell lines cov...
ORGANISM(S): Homo sapiens 
2019-05-28 | E-MTAB-7721 | biostudies-arrayexpress
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