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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
MetabolomicsMetabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part III
Not available
ORGANISM(S): Homo sapiens 
ST001237 | MetabolomicsWorkbench
MetabolomicsMetabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part II
Not available
ORGANISM(S): Homo sapiens 
ST001236 | MetabolomicsWorkbench
MetabolomicsMetabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part I
Not available
ORGANISM(S): Homo sapiens 
ST001235 | MetabolomicsWorkbench
MetabolomicsPalmitic Acid-Triggerd B7H3 Palmitoylation Promotes Immune Escape

B7H3 (CD276), a key immune checkpoint molecule that is overexpressed in tumors, plays a central role in cancer progression, making it a highly promising and specific therapeutic target. Here, we discovered that the cellular metabolite palmitic acid contributes to the development of an immunosuppr...

2025-12-03 | MTBLS12300 | MetaboLights
ProteomicsAnalysis of Immune Checkpoint Drug Targets and Tumor Proteotypes in Non-Small Cell Lung Cancer
New therapeutics targeting immune checkpoint proteins have significantly advanced treatment of non-small cell lung cancer (NSCLC), but protein level quantitation of drug targets presents a critical problem. We used multiplexed, targeted mass spectrometry (MS) to quantify the immunotherapy target pr...
ORGANISM(S): Homo Sapiens 
2020-06-22 | PXD019061 | panorama
GenomicsSequencing of patient samples who received immune checkpoint inhibition WES NKI
DNA and RNA isolated from FFPE blocks of patients who received immune checkpoint inhibition (ICI) are sequenced with the aim to identify therapeutically tractable vulnerabilities in tumors to prevent ICI resistance.
EGAS00001003154 | EGA
GenomicsImmune Checkpoint Associated Acute Interstitial Nephritis
Tertiary lymphoid structure signatures are associated with immune checkpoint inhibitor related acute interstitial nephritis
EGAD00010002406 | EGA
ModelsYu2019 - A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor
This is a mathematical model investigating interactions among malignant tumor cells, CD4+ T cells, anti-tumor cytokines (specifically IFN-gamma), and the immune checkpoint inhibitor CTLA-4 to assess the importance of immune checkpoints in mediating tumor regression.
2024-12-09 | MODEL1911270002 | BioModels
Immuno-oncology 
ProteomicsUsing proteomics and transcriptomics to explore the potential gene regulatory network of immune checkpoint inhibitors-related myocarditis
Immune checkpoint inhibitor-related myocarditis is the deadliest complication of immunotherapy. However, the underlying pathophysiological mechanisms of its occurrence and development remain unclear. Due to the long-term lack of effective early diagnosis and treatment options, it is of great signifi...
ORGANISM(S): Homo Sapiens 
2023-02-02 | PXD039793 |
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