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TranscriptomicsHigh throughput sequencing of immunoglobulin (Ig) heavy (IgH) and light (IgL) chain repertoires
We used 454 sequencing to assess the repertoire of B cell subsets from bone marrow, spleen, and small intestinal lamina propria from two mouse strains. We used a RAG2-GFP reporter mouse strain (129Sve background) to isolate CD19+ RAG2+ B lineage cells from bone marrow and small intestinal lamina pro...
ORGANISM(S): Mus musculus 
2013-07-16 | E-GEOD-48870 | biostudies-arrayexpress
ProteomicsRNA-based full length immunoglobulin light chain sequencing reveals lambda constant domain mutations with potential implications for thermodynamic stability in light chain amyloidosis
Background: Systemic light chain amyloidosis is a protein misfolding disorder characterized by deposition of clonal immunoglobulin light chains in vital organs. To date, little is known about the contribution of light chain constant domain mutations in thermodynamic stability and amyloidogenicity.Me...
ORGANISM(S): Homo sapiens (Human) 
2026-05-06 | PXD077140 | Pride
GenomicsRNA-based full length immunoglobulin light chain sequencing reveals lambda constant domain mutations with potential implications for thermodynamic stability in light chain amyloidosis
RNA-based full length immunoglobulin light chain sequencing
PRJEB109785 | ENA
UnknownA novel monoclonal antibody against the constant region of goose immunoglobulin light chain.
Not available
S-EPMC3998674 | biostudies-literature
UnknownEvolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion.
Not available
S-EPMC4379207 | biostudies-literature
GenomicsStereotyped B-cell responses are linked to IgG constant region polymorphisms in multiple sclerosis
Clonally related B cells infiltrate the brain, meninges, and cerebrospinal fluid of multiple sclerosis (MS) patients, but the mechanisms driving the B-cell response and shaping the immunoglobulin repertoires remain unclear. Here, we used single-cell full-length RNA-seq and B-cell receptor reconstruc...
EGAS00001005745 | EGA
UnknownQuantification of peptides from immunoglobulin constant and variable regions by LC-MRM MS for assessment of multiple myeloma patients.
Not available
S-EPMC4302417 | biostudies-literature
TranscriptomicsHigh throughput sequencing of immunoglobulin (Ig) heavy (IgH) and light (IgL) chain repertoires
We used 454 sequencing to assess the repertoire of B cell subsets from bone marrow, spleen, and small intestinal lamina propria from two mouse strains. We used a RAG2-GFP reporter mouse strain (129Sve background) to isolate CD19+ RAG2+ B lineage cells from bone marrow and small intestinal lamina pro...
ORGANISM(S): Mus musculus 
2013-07-16 | GSE48870 | GEO
UnknownA novel immunoglobulin-immunoglobulin interaction in autoimmunity.
Not available
S-EPMC2249926 | biostudies-literature
UnknownSequence analysis of feline immunoglobulin mRNAs and the development of a felinized monoclonal antibody specific to feline panleukopenia virus.
Not available
S-EPMC5629197 | biostudies-literature
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