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MetabolomicsTargeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in ARID1A-deficient triple negative breast cancer

Bone metastasis is a lethal consequence of breast cancer. AT-rich interaction domain 1A gene (ARID1A), a subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, regulates immunosuppressive tumor microenvironment. ARID1A deficient triple negative breast cancer promotes bone metastasis.To ...

2026-03-24 | MTBLS12768 | MetaboLights
MetabolomicsThe novel protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment
Metabolic reprogramming fuels cancer cell metastasis and remodels the immunosuppressive tumor microenvironment (TME). We report here that a circRNA, circPETH, packaged by extracellular vesicles (EVs) from tumor-associated macrophages (TAMs) to hepatocellular carcinoma (HCC) cells, facilitates glycol...
2024-12-09 | MTBLS11254 | MetaboLights
MetabolomicsMacrophage-specific BCAT1 deficiency drives lipid-associated immunosuppressive remodeling and promotes HCC progression

The heterogeneous and immunosuppressive tumor microenvironment (TME) remains one of the major factors to the poor immunotherapeutic response in hepatocellular carcinoma (HCC). Tumor-associated macrophages (TAMs) are central orchestrators of this suppressive niche, yet the metabolic programs regul...

2025-12-28 | MTBLS13579 | MetaboLights
ProteomicsTargeting TNK2 reverses the immunosuppressive tumor microenvironment and synergizes with immunochemotherapy in pancreatic cancer
In this study, we utilized spatial transcriptome analysis, genomic copy number variation mutation profiling, and single-cell sequencing to identify an abnormal overexpression of TNK2, which is inversely correlated with PDAC prognosis and the development of an immune-suppressive microenvironment. Pre...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-11 | PXD055503 | Pride
Immunosuppressive tumor microenvironment Immunotherapy resistance Pancreatic ductal adenocarcinoma Tnk2 
TranscriptomicsTranscription profiling of mouse CD11b cells purified from mouse spleen from umor-free and tumor-bearing mice
Active suppression of tumor-specific T lymphocytes can limit the immune-surveillance and immunotherapy efficacy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governi...
ORGANISM(S): Mus musculus 
2009-04-29 | E-GEOD-5455 | biostudies-arrayexpress
GenomicsImmunosuppressive tumor microenvironment of osteosarcoma [scRNA-seq]
Immunosuppressive tumor microenvironment of osteosarcoma [scRNA-seq]
PRJNA1272125 | ENA
GenomicsImmunosuppressive tumor microenvironment of osteosarcoma [Spatial transcriptomics]
Immunosuppressive tumor microenvironment of osteosarcoma [Spatial transcriptomics]
PRJNA1272124 | ENA
GenomicsAn oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment
An oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment
PRJNA779090 | ENA
GenomicsQuiescent tumor cells shape the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma [RNA-Seq]
Quiescent tumor cells shape the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma [RNA-Seq]
PRJNA1369309 | ENA
GenomicsQuiescent tumor cells shape the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma [Spatial Transcriptomics]
Quiescent tumor cells shape the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma [Spatial Transcriptomics]
PRJNA1369312 | ENA
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