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MetabolomicsPorcine epidemic diarrhea virus manipulates IMPDH-dependent nucleotide biosynthesis to facilitate replication

Porcine epidemic diarrhea virus (PEDV) causes acute intestinal disease in pigs and remains a major threat to the global swine industry due to its high morbidity and mortality in neonatal piglets. To investigate host metabolic alterations upon PEDV infection, we performed untargeted metabolomic pr...

2025-10-17 | MTBLS13153 | MetaboLights
TranscriptomicsDe Novo Purine Synthesis Mediates Circadian Control of Cell Cycle in Zebrafish (HTS)
Inosine 5'-phosphate dehydrogenase (impdh) has been well known as a key enzyme in GTP biosynthesis pathway. We found that three isoforms of impdh in zebrafish, namely impdh1a, impdh1b and impdh2, all show robust circadian expression.To examine the molecular functions of three impdh isoforms in zebra...
ORGANISM(S): Danio rerio 
2013-10-01 | E-GEOD-51278 | biostudies-arrayexpress
GenomicsGenome-wide IMPDH profiling in Drosophila larvae and S2 cells by ChIP-chip.
Division of labor is a central feature of cellular organization. Consequently, gene regulation and intermediary metabolism are generally believed to be conducted by strictly separate classes of proteins. Here, we show that inosine monophosphate dehydrogenase (IMPDH), the central enzyme in guanine nu...
ORGANISM(S): Drosophila melanogaster 
2012-05-01 | GSE29202 | GEO
UnknownCytoophidium assembly reflects upregulation of IMPDH activity.
Not available
S-EPMC4610212 | biostudies-literature
UnknownInterfilament interaction between IMPDH and CTPS cytoophidia.
Not available
S-EPMC6220823 | biostudies-literature
UnknownIMP/GTP balance modulates cytoophidium assembly and IMPDH activity.
Not available
S-EPMC6004095 | biostudies-literature
UnknownIMPDH inhibitors for antitumor therapy in tuberous sclerosis complex.
Not available
S-EPMC7205253 | biostudies-literature
UnknownReconstituted IMPDH polymers accommodate both catalytically active and inactive conformations.
Not available
S-EPMC5620369 | biostudies-literature
UnknownMolecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation.
Not available
S-EPMC11072341 | biostudies-literature
UnknownRepurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening.
Not available
S-EPMC6249553 | biostudies-literature
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