Sort   by:  
 Page size 
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
ProteomicsIn situ valence-transited arsenic nanosheets for multi-modal therapy of colorectal cancer
Late-stage and advanced colorectal cancer (CRC) often prove to be resistant to current treatment regimens, due to the evolving tumor microenvironment. Chemotherapy-dominated multi-modal therapeutic strategies based on the specific CRC microenvironment open a new horizon for eradicating colorectal tu...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD059728 | Pride
In situ microenvironment response Colorectal cancer treatment. Multi-modal therapy Arsenic valence transition 
TranscriptomicsTranscription profiling of human tumor microenvironment during breast cancer progression
To better understand the role of tumor microenvironment in breast cancer progression, we combined laser capture microdissection and microarray analysis to provide a comprehensive catalog of gene expression changes in both tumor and tumor-associated stroma. Experiment Overall Design: We used LCM to i...
ORGANISM(S): Homo sapiens 
2009-02-26 | E-GEOD-14548 | biostudies-arrayexpress
TranscriptomicsTranslating transcriptome of cancer cells in situ in mesenchymal-rich tumor microenvironment
A mesenchymal rich stroma such as cancer-associated fibroblasts (CAFs) in breast tumors favors the selection of cancer clones with enhanced bone metastatic ability. To determine the cancer cell transcriptomic response to the mesenchymal stroma, we supplemented experimental mammary tumours with or wi...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-43306 | biostudies-arrayexpress
ProteomicsIntegrating antigen capturing nanoparticles and type 1 conventional dendritic cell therapy for in situ cancer immunization
Eliciting a robust immune response against tumors is often hampered by the inadequate presence of effective antigen presenting cells and their suboptimal ability to present antigens within the immunosuppressive tumor microenvironment. Here, we report a cascade antigen relay strategy integrating anti...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-03 | PXD062399 | Pride
Antigen Cancer Orbitrap Mouse 
TranscriptomicsGene expression of LNCaP cells grown in 2D cultures and polyethlene glycol-based hydrogels with the presence of synthetic androgen, R1881
Analysis of LNCaP cell molecular differences and their response to R1881 in 2D and 3D cultures. Androgen regulated genes were differentially expressed between 2D and 3D cultures. These results provide insights into factors that influence the expression of androgen regulated genes In this study, LNCa...
ORGANISM(S): Homo sapiens 
2013-02-04 | E-GEOD-33610 | biostudies-arrayexpress
GenomicsTumor-resident T cells and dendritic cells form an in situ archetype for immunotherapy response in melanoma [scTCR-seq]
Tumor-resident T cells and dendritic cells form an in situ archetype for immunotherapy response in melanoma [scTCR-seq]
PRJNA1248926 | ENA
GenomicsTumor-resident T cells and dendritic cells form an in situ archetype for immunotherapy response in melanoma [scRNA-seq]
Tumor-resident T cells and dendritic cells form an in situ archetype for immunotherapy response in melanoma [scRNA-seq]
PRJNA1248923 | ENA
GenomicsTumor-resident T cells and dendritic cells form an in situ archetype for immunotherapy response in melanoma [bulk RNA-seq]
Tumor-resident T cells and dendritic cells form an in situ archetype for immunotherapy response in melanoma [bulk RNA-seq]
PRJNA1248920 | ENA
UnknownIn Situ Nitric Oxide Gas Nanogenerator Reprograms Glioma Immunosuppressive Microenvironment.
Not available
S-EPMC10288280 | biostudies-literature
Sort   by:  
 Page size