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MetabolomicsGlobal 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo
Liver metabolism is central to human physiology and influences the pathogenesis of common metabolic diseases. Yet, our understanding of human liver metabolism remains incomplete, with much of current knowledge based on animal or cell culture models that do not fully recapitulate human physiology. He...
2024-07-23 | MTBLS10481 | MetaboLights
MetabolomicsMetabolic differences between primary and brain metastatic breast tumors revealed by in vivo [U-¹³C]-glucose infusion in mice

Metastatic breast tumors must adapt to the metabolic constraints of their target tissues. To understand how tumor metabolism varies across sites, we compared glucose utilization in primary mammary fat pad (MFP) tumors and brain metastases derived from the breast cancer cell line MDA-MB-231. Tumor...

2025-12-30 | MTBLS13152 | MetaboLights
MetabolomicsPronounced uptake and metabolism of organic substrates by diatoms revealed by pulse-labeling metabolomics
Diatoms contribute as a major group of microalgae to approximately 20% of the global carbon fixation. In the plankton, these algae are exposed to a plethora of metabolites, especially when competing algae are lysed. In line with evidence that these phototrophs can also engage in heterotrophy we aske...
2021-12-09 | MTBLS2333 | MetaboLights
Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
MetabolomicsIsotope Labeled Reactivity-Based Metabolomics Reveal Cysteine as a Potent In Vivo Scavenger of Lactoylglutathione

Metabolite adducts are increasingly being recognized as important intermediates in cellular metabolism and as circulating messengers. Methylglyoxal (MG) is a highly reactive metabolite involved in diabetes and aging, via formation of a wide variety of protein adducts. Though new types of protein ...

2025-04-29 | MTBLS6287 | MetaboLights
MetabolomicsGlobal Stable-isotope Tracing Metabolomics Reveals System-wide Metabolic Alternations in Aging Drosophila

System-wide metabolic homeostasis is crucial for maintaining physiological functions of living organisms. Stable-isotope tracing metabolomics allows to unravel metabolic activity quantitatively by measuring the isotopically labeled metabolites, but has been largely restricted by coverage. Yet, de...

2022-06-16 | MTBLS3322 | MetaboLights
GenomicsIn vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart [bulk_slamseq]
In vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart [bulk_slamseq]
PRJNA1304420 | ENA
GenomicsIn vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart [scslam-seq]
In vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart [scslam-seq]
PRJNA1304419 | ENA
GenomicsIn vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart [scrna-seq]
In vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart [scrna-seq]
PRJNA1304412 | ENA
TranscriptomicsEffects of bisphenol A on gene expression in adipocytes from lean children: association to metabolic disorders
Bisphenol A (BPA) is a xenobiotic endocrine disrupting chemical. In vitro and in vivo studies indicated that BPA alters endocrine-metabolic pathways in adipose tissue increasing the risk of developing metabolic disorders. BPA effects on human adipocytes, specifically in children, are poorly investig...
ORGANISM(S): Homo sapiens 
2015-07-09 | E-GEOD-58516 | biostudies-arrayexpress
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