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UnknownGenome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers.
Targeting mutant KRAS signaling pathways continues to attract attention as a therapeutic strategy for KRAS-driven tumors. In this study, we exploited the power of the CRISPR-Cas9 system to identify genes affecting the tumor xenograft growth of human mutant KRAS (KRASMUT) colorectal cancer...
S-EPMC5690866 | biostudies-literature
UnknownGenome-wide CRISPR screening identifies tyrosylprotein sulfotransferase-2 as a target for augmenting anti-PD1 efficacy.

Background

Immune checkpoint therapy (ICT) provides durable responses in select cancer patients, yet resistance remains a significant challenge, prompting the exploration of underlying molecular mechanisms. Tyrosylprotein sulfotransferase-2 (TPST2), known for its role in protein tyrosine O-s...
S-EPMC11295332 | biostudies-literature
ProteomicsImmune surveillance of brain metastatic cancer cells is mediated by IFITM1 (Proteins identified in the >100 kDa fraction of conditioned media from all four cell lines)
The protein(s) larger than 100 kDa in conditioned medium from lung cancer cell lines activated microglia. The >100 kDa fraction of conditioned medium from H460, H1299, H2030, or H292 cells was collected. Proteins present in the conditioned medium were analyzed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD038129 | Pride
Non-small cell lung cancer Interferon-induced transmembrane protein 1 (ifitm1) Brain metastatic colonization In vivo pooled genome-wide loss-of-function genetic screen 
ProteomicsImmune surveillance of brain metastatic cancer cells is mediated by IFITM1 (The coimmunoprecipitated proteins associated with the endogenous membrane IFITM1 of H1299 cells after IFNγ stimulation)
To examine the molecular basis of IFITM1 function, we performed a coimmunoprecipitation (co-IP) assay of cell membrane proteins followed by mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD038130 | Pride
Non-small cell lung cancer Interferon-induced transmembrane protein 1 (ifitm1) Brain metastatic colonization In vivo pooled genome-wide loss-of-function genetic screen 
GenomicsA genome-wide CRISPR/Cas9-based functional screen uncovers the KLF4-Survivin/BIRC5 signaling pathway as a key regulator of cell fate following endoplasmic reticulum stress: Implications for tumor growth and therapeutic targeting
A genome-wide CRISPR/Cas9-based functional screen uncovers the KLF4-Survivin/BIRC5 signaling pathway as a key regulator of cell fate following endoplasmic reticulum stress: Implications for tumor growth and therapeutic targeting
PRJNA1108700 | ENA
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