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MetabolomicsNovel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model
Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health. Existing therapies including those based on minor groove binders (MGBs), such as the diamidines, which have been used for decades, have now lost efficacy ...
2022-01-18 | MTBLS882 | MetaboLights
TranscriptomicsEarly and Late gene expression responses to Salmonella infection in the mouse intestine
We used microarrays to detail the global programme of gene expression of the mouse colon responses to Salmonella (SL1344 and SB1117) infection at the early phase (8 hours) and the late phase (4 days). We specifically examined the the differentillay gene expression profiles in mouse colon when it re...
ORGANISM(S): Mus musculus 
2011-02-16 | E-GEOD-22215 | biostudies-arrayexpress
TranscriptomicsIn vivo transcriptome analysis of Toxoplasma gondii
This study utilizes global microarray analysis to identify how T. gondii alters its transcriptome in response to the in vivo microenvironment during the innate immune response (four days post-infection) relative to growth in fibroblast cells in vitro. To distinguish changes in the parasite transcri...
ORGANISM(S): Toxoplasma gondii 
2012-07-01 | E-MEXP-3579 | biostudies-arrayexpress
TranscriptomicsIn vivo transcriptome of Listeria monocytogenes EGDe
Time course study of the mouse infection by comparing the genomic transcriptional patterns of Listeria monocytogenes EGDe grown under laboratory conditions (exponential growth phase) with that of in vivo-grown bacteria (in mouse spleens) over three days of infection. Time course study of the mouse i...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-06-25 | E-GEOD-13057 | biostudies-arrayexpress
TranscriptomicsComparison of the expression profiles of the 630E strain after 8h, 14h and 38h of infection in mouse
The virulence factors of Clostridium difficile have been studied for many years, but the main in vivo pathogenesis processes of this bacterium has to be investigated. Especially, data on the early mechanisms of C. difficile adaptation to the host is not yet available. The objective of our study was ...
ORGANISM(S): [Clostridium] difficile 
2013-11-04 | E-GEOD-43303 | biostudies-arrayexpress
TranscriptomicsComparison of the expression profiles of R20291 strain : a wild type strain, a fliC mutant and a fliC mutant complemented after 14h of growth in PY and a wild type strain and a fliC mutant after 14h of mouse infection in vivo
Transcriptionnal profiling of C. difficile R20291 strain : a wild type strain, a fliC mutant and a fliC mutant complemented after 14h of growth in PY and a wild type strain and a fliC mutant after 14h of mouse infection in Vivo two-conditions experiments, R20291 strain : a wild type strain, a fliC m...
ORGANISM(S): [Clostridium] difficile 
2013-12-31 | E-GEOD-35727 | biostudies-arrayexpress
MetabolomicsDiallyl disulfide (DADS) ameliorates intestinal Candida albicans infection by modulating the gut microbiota and metabolites and providing intestinal protection in mice
Diallyl disulfide (DADS), a garlic extract also known as allicin, has been reported to have numerous biological activities, including anticancer, antifungal, and inflammation-inhibiting activities, among others. Although many studies have assessed whether DADS can treat Candida albicans infec...
2022-05-03 | MTBLS3750 | MetaboLights
TranscriptomicsPneumonia infection, lung and liver inflammation
Vaccination reduces morbidity and mortality from pneumonia but its effect on the tissue-level response to infection is still poorly understood. We evaluated pneumonia disease progression, acute phase response and lung gene expression profiles in mice inoculated intranasally with virulent gram-positi...
ORGANISM(S): Mus musculus 
2013-03-29 | E-GEOD-45644 | biostudies-arrayexpress
TranscriptomicsActivity of SigB Modulates Virulence Gene Expression in a Murine Staphylococcus aureus Infection Model but Does Not Influence the Host Kidney Gene Expression
Background. Infections caused by Staphylococcus aureus are associated with significant morbidity and mortality and are an increasing threat not only in hospital settings. The expression of the staphylococcal virulence factor repertoire is known to be affected by the alternative sigma factor B (SigB...
ORGANISM(S): Mus musculus 
2011-10-23 | E-GEOD-28540 | biostudies-arrayexpress
TranscriptomicsComplex in vivo RNA-seq analysis reveal reprogramming of Yersinia from virulent to persistent mode during infection [RNA-seq]
We recently found that Yersinia pseudotuberculosis can be used as a model of persistent bacterial infections. We performed in vivo RNA-seq of bacteria in small cecal tissue biopsies at early and persistent stages of infection to determine strategies associated with persistence. Comprehensive analysi...
ORGANISM(S): Yersinia pseudotuberculosis YPIII 
2014-12-05 | E-GEOD-55292 | biostudies-arrayexpress
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