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MetabolomicsMicrobiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
Anti-programmed death 1 (αPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular toxicity. Finding drugs that suppress cardiovascular toxicity but not compromise the efficacy of αPD1-mediated immunotherapy is of great importance. Leflunomide (L...
2025-03-12 | MTBLS12066 | MetaboLights
ProteomicsMicrobial metabolite Indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation
The gut microbiota and its metabolites critically regulate immune cell phenotype, function, and energy metabolism. We screened a collection of gut microbiota-related metabolites to identify modulators of mitochondrial metabolism in T cells. Here, we show that indole-3-propionic acid (IPA) stimulates...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-28 | PXD057537 | Pride
Gut microbiota Indole-3-propionic acid (ipa) Immunometabolism Inflammatory bowel disease (ibd) Cd4+ t cell 
GenomicsChemotherapy-driven intestinal dysbiosis and microbial indole-3-propionic acid rewire bone marrow myelopoiesis to promote anti-metastatic immunity
Chemotherapy-driven intestinal dysbiosis and microbial indole-3-propionic acid rewire bone marrow myelopoiesis to promote anti-metastatic immunity
PRJNA1191025 | ENA
TranscriptomicsRNA sequencing of L4-L6 mouse Dorsal Root Ganglia 3 days post sciatic nerve crush and naive following 10 days of Indole-3-propionic acid treatment
Purpose: compare the response of DRG neurons to indole-3-propionic acid treatment before and after sciatic nerve injury Results: we found that IPA induced transcription changes before and after injury inside the DRG tissue. In particular expression of immune system related genes
ORGANISM(S): Mus musculus 
2022-01-01 | GSE161342 | GEO
GenomicsRNA sequencing of L4-L6 mouse Dorsal Root Ganglia 3 days post sciatic nerve crush and naive following 10 days of Indole-3-propionic acid treatment
RNA sequencing of L4-L6 mouse Dorsal Root Ganglia 3 days post sciatic nerve crush and naive following 10 days of Indole-3-propionic acid treatment
PRJNA677927 | ENA
GenomicsMaternal Helminths Rewire the Microbiota to Promote Offspring Antiviral Immunity via Indole-3-Propionic Acid
Maternal Helminths Rewire the Microbiota to Promote Offspring Antiviral Immunity via Indole-3-Propionic Acid
PRJNA1274826 | ENA
TranscriptomicsMaternal Helminths Rewire the Microbiota to Promote Offspring Antiviral Immunity via Indole-3-Propionic Acid
Maternal environmental exposures are critical in shaping offspring immunity. Yet, the role of helminths, mammals’ symbiotic evolutionary partners that have been eliminated from modern societies, remains poorly understood. Here, we show that maternal helminth infection enhances type I interferon (IFN...
ORGANISM(S): Mus musculus 
2026-07-01 | GSE299495 | GEO
UnknownIndole-3-propionic acid promotes hepatic stellate cells inactivation.
Not available
S-EPMC11871697 | biostudies-literature
UnknownNew Indole-3-Propionic Acid and 5-Methoxy-Indole Carboxylic Acid Derived Hydrazone Hybrids as Multifunctional Neuroprotectors.
Not available
S-EPMC10135567 | biostudies-literature
UnknownIndole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction.
Not available
S-EPMC10923103 | biostudies-literature
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