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MetabolomicsMulti-omics analysis reveals ToMMV-induced regulation of amino acid and phenylpropanoid biosynthesis pathways affecting tomato fruit quality and resistance

Tomato mottle mosaic virus (ToMMV) is a major threat to cultivating tomatoes and other solanaceous plants. Here, an infectious clone of the ToMMV Huludao isolate was constructed, and ToMMV infection significantly reduces soluble sugar, soluble phenolic and vitamin C ...

2025-09-01 | MTBLS12864 | MetaboLights
ModelsGreene2019 - Differentiate Spontaneous and Induced Evolution to Drug Resistance During Cancer Treatment
This model is built by COPASI 4.24(Build 197), based on paper: Mathematical Approach to Differentiate Spontaneous and Induced Evolution to Drug Resistance During Cancer Treatment. Author: James M. Greene, Jana L. Gevertz, Eduardo D. sontag Abstract: PURPOSE:Drug resistance is a major impediment to...
2024-09-02 | BIOMD0000000825 | BioModels
TranscriptomicsTranscription profiling of mouse small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J strain.
Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain more insight in the role of the small intestine in the etiology of these metabolic disorders, a microarray study was performed on small intestines (SI) of C57BL/6J mice that were fed a high fat diet ...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-8582 | biostudies-arrayexpress
TranscriptomicsIL-37 protects against obesity-induced inflammation and insulin resistance
Cytokines of the IL-1 family are important modulators of obesity-induced inflammation and the development of systemic insulin resistance. Here, we report that IL-37, a newly-described antiinflammatory member of the IL-1 family, affects obesity-induced inflammation and insulin resistance. IL-37 trans...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-58952 | biostudies-arrayexpress
GenomicsComprehensive analysis of different in vitro insulin resistance models
Diet-induced obesity (DIO) predisposes individuals to insulin resistance, and adipose tissue has a major role in the disease. Insulin resistance can be induced in cultured adipocytes by a variety of treatments, but what aspects of the in vivo responses are captured by these models remains unknown. W...
ORGANISM(S): Mus musculus 
2013-10-18 | E-GEOD-35724 | biostudies-arrayexpress
ModelsWilkie2013r - immune-induced cancer dormancy and immune evasion-resistance
The paper describes a model of immune-induced cancer dormancy and immune evasion with resistance. Created by COPASI 4.25 (Build 207) This model is described in the article: Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion Kathleen P. Wilkie and Philip Hah...
2024-09-02 | BIOMD0000000752 | BioModels
Immuno-oncology 
TranscriptomicsOntogenic Resistance in Apple
Ontogenic scab resistance in apple leaves and fruits is a horizontal resistance against the plant pathogen VenturiaM- inaequalis and is expressed as decrease of disease symptoms and incidence with the ageing of the leaves. Several studies at biochemical level tried to unveil the nature of this resis...
ORGANISM(S): Malus domestica 
2013-11-18 | E-MTAB-1726 | biostudies-arrayexpress
TranscriptomicsGermfree C57BL/6J mice are resistant to high fat diet-induced insulin resistance and have altered cholesterol metabolism
Germfree (GF) mice have been used as a model to study the contribution of the intestinal microbiota to metabolic energy balance of the host. Despite a wealth of knowledge accumulated since the 1940’s, the response of GF mice to a high fat diet is largely unknown. In the present study, we compared th...
ORGANISM(S): Mus musculus 
2010-08-20 | E-GEOD-19038 | biostudies-arrayexpress
GenomicsCHS101 Dronedarone Induced resistance S. aureus
CHS101 Dronedarone Induced resistance S. aureus Genome sequencing and assembly
PRJNA901623 | ENA
TranscriptomicsCluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy
Overall, the widely disparate transcriptomes identified prior to RT among the three clusters support the notion that at least some of the inter-individual heterogeneity in propensity for RT-induced myofiber hypertrophy is likely pre-determined. Baseline comparisons of skeletal muscle transcript prof...
ORGANISM(S): Homo sapiens 
2013-05-24 | E-GEOD-42507 | biostudies-arrayexpress
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