Sort   by:  
 Page size 
ProteomicsInfected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria.
Severe malaria (SM) is a life-threatening condition caused by Plasmodium falciparum and the most severe presentation is cerebral malaria (CM) mostly affecting children under five years old. The comprehensive understanding of the complex mechanisms driving the pathophysiology of CM, which encompasses...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2024-02-01 | PXD042503 | Pride
Infected erythrocytes Severe malaria Plasma Infected erythrocytes severe malaria Plasmodium falciparum Lc-ms/ms 
ProteomicsInfected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria
Cerebral malaria (CM), the most lethal complication of Plasmodium falciparum severe malaria (SM), claims the life of 15 to 25% of admitted children despite treatment. P. falciparum infects and multiplies in human erythrocytes, contributing to anemia, parasite sequestration, and inflammation in the h...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2024-02-01 | PXD043033 | Pride
Severe malaria Plasma Plasmodium falciparum Lc-ms/ms 
TranscriptomicsDual RNA-seq of peripheral blood from Gambian children with severe or uncomplicated Plasmodium falciparum malaria
This study examined the differences in human and parasite gene expression pattern between children with severe malaria and those with uncomplicated malaria through a dual RNA-seq approach. Peripheral blood samples were collected which contained substantial numbers of parasites that required no RNA e...
ORGANISM(S): Homo sapiens 
2018-06-20 | E-MTAB-6413 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Plasmodium falciparum for comparative analysis of clinical isolates with severe and uncomplicated malaria.
Genome wide transcriptome analyses could reveal whether parasites causing severe malarial disease express different genes to those causing uncomplicated malaria. This knowledge could inform therapy and vaccine design targeting severe disease. Venous samples were collected from patients with severe (...
ORGANISM(S): Plasmodium falciparum 
2018-02-08 | E-MTAB-5860 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the malaria parasite Plasmodium falciparum 3D7 during its intraerythrocytic development cycle
The parasite Plasmodium falciparum is responsible for severe malaria, which is still one of the major causes of death in developing countries. To provide a new RNA-seq reference dataset for its blood-stage transcriptome according to current guidelines and best practices, we performed a time course e...
ORGANISM(S): Plasmodium falciparum 3D7 
2019-07-02 | E-MTAB-7731 | biostudies-arrayexpress
TranscriptomicsAcute Lung Injury In Experimental Malaria
Although respiratory distress is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria; however, no model of malaria-i...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-9497 | biostudies-arrayexpress
TranscriptomicsNatural anitsense transcripts in Plasmodium vivax clinical isolates
Plasmodium vivax is the most geographically widespread human malaria parasite causing approximately 130-435 million infections annually. It is an economic burden in many parts of the world and poses a public health challenge along with the other Plasmodium sp. The biology of this parasite is very li...
ORGANISM(S): Plasmodium vivax 
2014-01-16 | E-GEOD-45165 | biostudies-arrayexpress
TranscriptomicsDifferent PfEMP1-expressing Plasmodium falciparum variants induce divergent endothelial transcriptional responses during cytoadherence
The pathogenesis of severe malaria is complex and involves several pathways that influence host inflammation and endothelial function. The human malaria parasite Plasmodium falciparum is responsible for the majority of mortality and morbidity caused by malaria infection and differs from other human...
ORGANISM(S): Homo sapiens 
2023-11-01 | E-MTAB-12730 | biostudies-arrayexpress
UnknownInfected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria.
Not available
S-EPMC10897182 | biostudies-literature
UnknownRecruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.
Not available
S-EPMC6608510 | biostudies-literature
Sort   by:  
 Page size