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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
GenomicsDeconstructing synthetic inflammasomes in tumors drives diverse antitumor responses
Deconstructing synthetic inflammasomes in tumors drives diverse antitumor responses
PRJNA1086391 | ENA
TranscriptomicsDeconstructing synthetic inflammasomes in tumors drives diverse antitumor responses
Inflammasomes are cardinal defense machines that utilize cytokine and immunogenic cell death components to engage the immune system against pathogens. On the other hand, inflammasomes have ambiguous and context-dependent roles in cancers that are known to downregulate effectors of immunogenic cell d...
ORGANISM(S): Mus musculus 
2024-11-12 | GSE261286 | GEO
GenomicsHedgehog Induced ZFYVE21 Activates T Cell Intrinsic, NLRP3 Inflammasomes to Promote Chronic Inflammation
Hedgehog Induced ZFYVE21 Activates T Cell Intrinsic, NLRP3 Inflammasomes to Promote Chronic Inflammation
PRJNA859527 | ENA
UnknownInflammasomes and Colorectal Cancer.
Not available
S-EPMC8467678 | biostudies-literature
UnknownInflammasomes and autoimmunity.
Not available
S-EPMC3057120 | biostudies-literature
UnknownRoles of inflammasomes in viral myocarditis.
Not available
S-EPMC10225676 | biostudies-literature
UnknownThe NAIP/NLRC4 inflammasomes.
Not available
S-EPMC4336817 | biostudies-literature
ProteomicsIncoming poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human cells
The innate immune system recognizes cytosolic DNA as evidence of infection, although detailed analysis is mostly limited to mice and cell lines. To investigate inflammasome responses in human primary cells, we used the inflammasome reporter caspase-1CARD-EGFP (C1C-EGFP) encoded in engineered viruses...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD069678 | Pride
UnknownUnanticipated Loss of Inflammasomes in Birds.
Not available
S-EPMC11258412 | biostudies-literature
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