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MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
ProteomicsProteomics characterization of the inner membrane domain (IMD) from Mycobacterium tuberculosis
The inner membrane domain (IMD) is a metabolically active and laterally discrete membrane domain initially discovered in Mycobacterium smegmatis that correlates both temporally and spatially with polar cell envelope elongation. While it has remained unclear whether a similar membrane domain exists i...
ORGANISM(S): Mycobacterium tuberculosis TBR27 
2025-11-21 | PXD069609 | Pride
Proteomics Mycobacterium tuberculosis Inner membrane domain Infectious disease Microbiology 
ProteomicsThe inner nuclear membrane-associated degradation system in plants
The homeostasis of the inner nuclear membrane (INM) proteins plays a critical role in regulating the nuclear structure, genome integrity, and signal transduction. However, little is known about the turnover of INM proteins in higher eukaryotes. Here we demonstrated that the conserved INM protein SUN...
ORGANISM(S): Arabidopsis Thaliana 
2020-03-11 | PXD015920 |
GenomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly
ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly
PRJNA773755 | ENA
TranscriptomicsRequirement for Sun1 in the expression of meiotic reproductive genes and piRNA
The inner nuclear envelope (NE) proteins interact with the nuclear lamina and participate in the architectural compartmentalization of chromosomes. The association of NE proteins with DNA contributes to the spatial rearrangement of chromosomes and their gene expression. Sun1 is an inner nuclear memb...
ORGANISM(S): Mus musculus 
2009-03-11 | E-GEOD-12867 | biostudies-arrayexpress
TranscriptomicsIncrease in membrane cholesterol of neurons in culture recapitulates AlzheimerM-bM-^@M-^Ys disease early phenotypes.
Levels of membrane-associated cholesterol were shown to be increased in the brain of individuals with sporadic AlzheimerM-bM-^@M-^Ys disease (AD) and correlated with the severity of the disease. We previously found that heavy membrane cholesterol burden promotes amyloid precursor protein (APP) endoc...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-GEOD-46221 | biostudies-arrayexpress
TranscriptomicsAscites enriches for ovarian cancer stem-like cells that express membrane GRP78
Ovarian cancer patients are generally diagnosed at stage III/IV, when ascites is common. The volume of ascites positively correlates with the extent of metastasis and negatively with prognosis. Membrane GRP78, a stress-inducible endoplasmic reticulum chaperone which also appears on the plasma membra...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-61285 | biostudies-arrayexpress
TranscriptomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly
The ATPase Family AAA Domain Containing 3A (ATAD3A) is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary role, ...
ORGANISM(S): Mus musculus 
2021-12-30 | GSE186409 | GEO
TranscriptomicsThe plasma membrane NADPH oxidase OsRbohA plays a crucial role in developmental regulation and drought-stress response in rice
Plasma membrane NADPH oxidases (NOXs) are major producers of reactive oxygen species (ROS) in plant cells under normal growth and stress conditions. Rice NOXs have multiple homologs but their functional mechanisms are largely unknown. We used microarrays to detail the global gene expression profiles...
ORGANISM(S): Oryza sativa Japonica Group 
2015-12-31 | E-GEOD-54466 | biostudies-arrayexpress
UnknownMCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis.
Not available
S-EPMC5561183 | biostudies-literature
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