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ProteomicsA new NO-independent immunomodulatory function for iNOS in regulating itaconate production via mitochondrial protein-protein interaction with IRG1
iNOS modulates itaconate metabolism by a novel conformation-dependent protein-protein interaction separate from iNOS-mediated NO generation.
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD048712 | Pride
Macrophages Tca cycle by cis-aconitate decarboxylase Inos and irg1 
GenomicsCITE-seq analysis of Mycobacterium tuberculosis infected Irg1- and iNOS-deficient mouse lungs
CITE-seq analysis of Mycobacterium tuberculosis infected Irg1- and iNOS-deficient mouse lungs
PRJNA1072641 | ENA
UnknownIRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila.
Not available
S-EPMC6851286 | biostudies-literature
TranscriptomicsCITE-seq analysis of Mycobacterium tuberculosis infected Irg1- and iNOS-deficient mouse lungs
Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths a year. However, tuberculosis pathogenesis remains poorly understood and is not fully recapitulated in standard mouse models. Here we report that a comparison across three different susceptible mouse models identifies Mtb-induced gene signat...
ORGANISM(S): Mus musculus 
2026-04-01 | GSE254926 | GEO
UnknownItaconate confers tolerance to late NLRP3 inflammasome activation.
Not available
S-EPMC8039864 | biostudies-literature
UnknownChicken innate immune response to oral infection with Salmonella enterica serovar Enteritidis.
Not available
S-EPMC3663788 | biostudies-literature
UnknownA balanced game: chicken macrophage response to ALV-J infection.
Not available
S-EPMC6404279 | biostudies-literature
UnknownBotulinum neurotoxin type A induces TLR2-mediated inflammatory responses in macrophages.
Not available
S-EPMC4390353 | biostudies-literature
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