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MetabolomicsMetabolomics study for investigating the specific role of INOSITOL-REQUIRING ENZYME 1A and INOSITOL-REQUIRING ENZYME 1B under chronic endoplasmic reticulum stress in Arabidopsis thaliana

The Unfolded Protein Response (UPR) is a retrograde, ER-to-nucleus, signalling pathway which is conserved across kingdoms. In plants, it contributes to development, reproduction, immunity and tolerance to abiotic stress. This metabolomic dataset was produced from 14-day-old Arabidopsis thaliana s...

2024-12-02 | MTBLS10609 | MetaboLights
GenomicsA nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth
A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth
PRJNA1207135 | ENA
ProteomicsleA nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth
Endoplasmic-reticulum resident inositol-requiring enzyme 1alpha(IRE1) supports protein homeostasis via a cytoplasmic kinase-RNase module. Known cancer dependency on IRE1 entails its enzymatic activation of the transcription factor XBP1s and of RNA decay. We discovered that some cancer cells require ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-22 | MSV000093902 | MassIVE
TranscriptomicsA nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth
Endoplasmic-reticulum resident inositol-requiring enzyme 1a (IRE1) supports protein homeostasis via its cytoplasmic kinase-RNase module. Known cancer dependency on IRE1 entails its enzymatic activation of the transcription factor XBP1s and of regulated RNA decay. We discovered that some cancer cells...
ORGANISM(S): Homo sapiens 
2025-01-07 | GSE285981 | GEO
UnknownInositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth.
Not available
S-EPMC7726810 | biostudies-literature
UnknownBinding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain.
Not available
S-EPMC6217623 | biostudies-literature
UnknownInositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs.
Not available
S-EPMC5204310 | biostudies-literature
UnknownInositol-Requiring Enzyme 1-Dependent Activation of AMPK Promotes Brucella abortus Intracellular Growth.
Not available
S-EPMC4772604 | biostudies-literature
UnknownOpposite Roles of RNase and Kinase Activities of Inositol-Requiring Enzyme 1 (IRE1) on HSV-1 Replication.
Not available
S-EPMC5618002 | biostudies-literature
UnknownInositol-Requiring Enzyme-1 Regulates Phosphoinositide Signaling Lipids and Macrophage Growth
Not available
S-SCDT-EMBOR-2020-51462V1 | biostudies-other
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