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TranscriptomicsThe role of AR-associated factors in androgen signaling
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. We identified androgen-regulated genes, CTBP2, FOXP1 and RUNX1. These factors interact with AR ligand dependently. In order to investigate androgen-regulated gene functions in pr...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-58309 | biostudies-arrayexpress
GenomicsGenome wide mapping of AR and its associated factors in prostate cancer
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and its associated factors such as coregulators or collaborating factors.In addition, by siRNA mediated knockdown of s...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-58428 | biostudies-arrayexpress
GenomicsGenome wide analysis of AR binding sites and histone modifications in prostate cancer
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and histone modifications.In addition, by siRNA mediated knockdown of AR-associated factors, changes of AR-binding sit...
ORGANISM(S): Homo sapiens 
2015-02-08 | E-GEOD-62492 | biostudies-arrayexpress
TranscriptomicsEffects of PSF and CTBP1-AS knockdown in prostate cancer cell lines
Prostate cancer is the most common cancer in men and Androgen receptor (AR) downstream signalings promote prostate cancer cell proliferation. We identified androgen-regulated long non-coding RNA, CTBP1-AS, located in the antisese region of CTBP1 gene. CTBP1-AS activate AR signaling by epigeneticall...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-44264 | biostudies-arrayexpress
TranscriptomicsEffects of Oct1 inhibition in AR signaling
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. Oct1 is an AR interacting partner and regulates the transcriptional activity of AR. In order to investigate the Oct1 function in prostate cancer cells, we performed gene expressi...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-77650 | biostudies-arrayexpress
TranscriptomicsEffects of RUNX1 knockdown in AR signaling
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. We identified RUNX1 is an androgen-regulated gene. In order to investigate the RUNX1 function in prostate cancer cells, we performed gene expression in AR-positive prostate cance...
ORGANISM(S): Homo sapiens 
2014-10-18 | E-GEOD-62454 | biostudies-arrayexpress
TranscriptomicsEffects of miRNA-mediated TET2 in prostate cancer
Prostate cancer is the most common cancer in men. We identified that miR-29 family is the most androgen-responsive miRNA in hormone-refractory prostate cancer cells. For the screening of miR-29b target, we performed microarray analysis in two prostate cancer cells. Because TET2 is the primary targe...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-66038 | biostudies-arrayexpress
TranscriptomicsEffects of SOCS2-AS1 inhibition in prostate cancer cells
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. We identified a novel androgen-regulated long non-coding (lnc) RNA, SOCS2-AS1. In order to investigate the SOCS2-AS1 function in prostate cancer cells, we performed gene expressi...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-82224 | biostudies-arrayexpress
TranscriptomicsATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory (expression)
Immunological memory is generally thought to be mediated exclusively by lymphocytes such as memory T and B cells. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection suggesting the presence of innate immunological memory. Here, we describe...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71111 | biostudies-arrayexpress
ProteomicsProteome analysis of mouse liver and skeletal muscle
The liver and skeletal muscle were collected from 10-week-old wild-type and ob/ob mice fasted for 16 hours. Tissues were frozen immediately and lysed with 0.5 mL of a solution containing 50 mM Tris-HCl pH8.8, 2%SDS, and 7 M urea, and then subjected to ultrasonic treatment with a Bioruptor (Digaenode...
ORGANISM(S): Mus Musculus (mouse) 
2021-03-03 | PXD020656 | JPOST Repository
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