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ProteomicsA proteomics approach to isolating neuropilin-dependent α5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic α5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells
Integrin trafficking to and from membrane adhesions is a crucial mechanism that dictates many aspects of a cell’s behaviour, including motility, polarisation, and invasion. In endothelial cells (ECs), the intracellular traffic of α5-integrin is regulated by both neuropilin 1 (NRP1) and neuropilin 2 ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-20 | PXD051778 | Pride
Sprouting angiogenesis Integrin trafficking Neuropilins Endothelial cell Retina 
TranscriptomicsKlf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated membrane Beta1/Beta2-integrin expression
The Kruppel-like factor 5 (Klf5) regulates pluripotent stem cell self-renewal but its role in somatic stem cells is unknown. Klf5 deficient hematopoietic stem cells and progenitors (HSC/P) fail to engraft after transplantation. This HSC/P defect was associated with impaired bone marrow (BM) homing a...
ORGANISM(S): Mus musculus 
2013-01-30 | E-GEOD-43806 | biostudies-arrayexpress
Unknownalpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration.
Not available
S-EPMC2064808 | biostudies-literature
UnknownPhosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance.
Not available
S-EPMC3037412 | biostudies-literature
UnknownPhosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells.
Not available
S-EPMC3266520 | biostudies-literature
UnknownTβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells.
Not available
S-EPMC3835656 | biostudies-literature
UnknownThe WASH-complex subunit Strumpellin regulates integrin αIIbβ3 trafficking in murine platelets.
Not available
S-EPMC10260982 | biostudies-literature
ModelsJafarnejad2019 - Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma
Hepatocyte growth factor (HGF) signaling through its receptor Met has been implicated in hepatocellular carcinoma tumorigenesis and progression. Met interaction with integrins is shown to modulate the downstream signaling to Akt and ERK (extracellular-regulated kinase). In this study, we developed a...
2020-03-20 | MODEL2003200001 | BioModels
UnknownR-Ras regulates beta1-integrin trafficking via effects on membrane ruffling and endocytosis.
Not available
S-EPMC2830936 | biostudies-literature
UnknownNovel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.
Not available
S-EPMC6369592 | biostudies-literature
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