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MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina
Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 37,982 cells from diabetic...
2026-03-30 | MTBLS14184 | MetaboLights
MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina

Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 18,926 cells from...

2026-03-27 | MTBLS13544 | MetaboLights
MetabolomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
Intestinal barrier dysfunction is a hallmark of gastrointestinal disorders, including inflammatory bowel diseases (IBD). In IBD, the disruption of the gut barrier causes liquid loss and persistent immune response. Understanding the cellular events underlying epithelial barrier disruption during chro...
2026-04-01 | MTBLS14166 | MetaboLights
MetabolomicsFermented cotton stalks preserve colonic epithelial integrity in Hu sheep by modulating the microbiota–metabolite–NF-kB/MLCK axis

This study compared three cotton-stalk processing strategies—grinding (FS), steam explosion (PH), and microbial fermentation (FJ)—and evaluated whether the barrier-preserving phenotype observed with fermented cotton stalks is associated with coordinated changes in the microbiota–metabolite milieu...

2026-03-18 | MTBLS14078 | MetaboLights
MetabolomicsDietary lactoferrin supplementation enhances immune function, improves intestinal integrity and reshapes gut microbiota in kittens

Background: Lactoferrin is a natural iron-binding glycoprotein with antimicrobial, immunomodulatory and barrier-protective activities, and it is widely applied in human nutritional supplements and infant food additives, but its application potential in pet food remains undetermined. Th...

2026-04-20 | MTBLS13713 | MetaboLights
MetabolomicsKarenia brevis allelopathy compromises the lipidome, membrane integrity, and photosynthetic efficiency of competitors
Not available
ORGANISM(S): Thalassiosira pseudonana;Karenia brevis 
ST000921 | MetabolomicsWorkbench
MetabolomicsCommensal intestinal microbiota regulates host luminal proteolytic activity and intestinal barrier integrity through β-glucuronidase activity
Not available
ORGANISM(S): Homo sapiens 
ST001718 | MetabolomicsWorkbench
TranscriptomicsMeasure transcript integrity using RNA-seq data
Achieved biospecimens annotated with patient clinical characteristics are unique resources for translational research. However, RNA extracted from the achieved tissues is often degraded. RNA degradation can have a significant impact on the measure of transcript abundance that can lead to an increase...
ORGANISM(S): Homo sapiens 
2016-02-19 | E-GEOD-70285 | biostudies-arrayexpress
MetabolomicsCommensal intestinal microbiota regulates host luminal proteolytic activity and intestinal barrier integrity through β-glucuronidase activity (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST002090 | MetabolomicsWorkbench
MetabolomicsCommensal intestinal microbiota regulates host luminal proteolytic activity and intestinal barrier integrity through β-glucuronidase activity (Part 1)
Not available
ORGANISM(S): Homo sapiens 
ST002094 | MetabolomicsWorkbench
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