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MetabolomicsA microfluidics-based in vitro model of the gastrointestinal human-microbe interface
Changes in the human gastrointestinal microbiome are associated with several diseases. To infer causality, experiments in representative models are essential, but widely used animal models exhibit limitations. Here we present a modular, microfluidics-based model (HuMiX, human–microbial crosstalk), w...
2017-07-28 | MTBLS328 | MetaboLights
MetabolomicsLimited vertical transmission but profound immune dysregulation at the maternal-fetal interface after SARS-CoV-2 infection

The endemic of SARS-CoV-2 underscores the imperative to elucidate its effects on pregnancy, particularly regarding the potential for vertical transmission and its influence on the early maternal-fetal interface, which remain insufficiently defined. To address this, we performed an extensive cohor...

2026-03-05 | MTBLS13103 | MetaboLights
MetabolomicsMaternal Gut Microbiota Influences Immune Activation at the Maternal-Fetal Interface Affecting Pregnancy Outcome

Preeclampsia is a leading cause of morbidity and mortality in pregnant women, affecting 5-8% of gestations worldwide. Its development is influenced by maternal immune abnormalities, metabolic disorders and gut dysbiosis. In this study, we show that gut dysbiosis in pregnant C57BL/6J dams leads to...

2025-05-07 | MTBLS12316 | MetaboLights
MetabolomicsSingle-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance
Multi-drug resistance (MDR) is an almost inevitable end point of cancer therapy, driving rapid tumor progression, yet its evolutionary logic remains unclear because MDR tumors are rarely resected. Using paired therapy-naive and MDR melanoma specimens from a clinical trial, integrated with single-cel...
2027-08-13 | MTBLS15322 | MetaboLights
TranscriptomicsSevere Preeclampsia-Related Changes in Gene Expression at the Maternal-Fetal Interface Include Siglec-6 and Pappalysin-2
Preeclampsia (PE), which affects 4-8% of human pregnancies, causes significant maternal and neonatal morbidity and mortality. Within the basal plate, placental cytotrophoblasts (CTBs) of fetal origin invade the uterus and extensively remodel the maternal vasculature. In PE, CTB invasion is often sha...
ORGANISM(S): Homo sapiens 
2009-02-06 | E-GEOD-14722 | biostudies-arrayexpress
TranscriptomicsStem cells rejuvinate the schistosome host-parasite interface
Schistosomes infect more than 200 million of the world's poorest people. These parasites live in the vasculature, producing eggs that spur a variety of chronic, potentially life-threatening, pathologies exacerbated by the long lifespan of schistosomes, that can thrive in the host for decades. How sc...
ORGANISM(S): Schistosoma mansoni 
2015-12-10 | E-GEOD-75861 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array to investigate the effect of interfacial stress on rat alveolar type II cell signalling and gene expression (conventional air-liquid interface)
Many epithelia have contact with air-liquid interfaces. This applies particularly to the lung, where one of the epithelial cell types (the surfactant secreting alveolar type II [AT II] cells) even project into the air. This specific environment may be of considerable physiological relevance; however...
ORGANISM(S): Rattus norvegicus 
2012-07-20 | E-MEXP-3363 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array to investigate the effect of interfacial stress on rat alveolar type II cell signalling and gene expression (inverted air-liquid interface)
Many epithelia have contact with air-liquid interfaces. This applies particularly to the lung, where one of the epithelial cell types (the surfactant secreting alveolar type II [AT II] cells) even project into the air. This specific environment may be of considerable physiological relevance; however...
ORGANISM(S): Rattus norvegicus 
2012-07-20 | E-MEXP-3372 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human 27 non-labored normal preterm and 9 non-labored normal term basal plate samples to investigate gene expression at the human maternal-fetal interface
Microarray analysis to globally assess gene expression at the maternal-fetal interface Experiment Overall Design: 27 non-labored normal preterm and 9 non-labored normal term basal plate samples were analyzed on Affymetrix U133 chips using established protocols. The gene expression profile of prete...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-5999 | biostudies-arrayexpress
GenomicsTest ENA interface
This is a test study to see how the ENA interface works.
PRJEB6692 | ENA
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