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MetabolomicsAccumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex
Secondary metabolites are involved in the plant stress response. Among these are scopolin and its active form scopoletin, which are coumarin derivatives associated with reactive oxygen species scavenging and pathogen defence. Here we show that in Arabidopsis thaliana, scopolin accumulation can be in...
2018-02-05 | MTBLS389 | MetaboLights
TranscriptomicsAntiviral RNA interference in mammalian cells
Plants and invertebrates protect themselves from viruses through RNA interference (RNAi), yet it remains unknown whether this defense mechanism exists in mammals. Antiviral RNAi involves the processing of viral long double-stranded (ds) RNA molecules into small interfering RNAs (siRNAs) by the ribon...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-43153 | biostudies-arrayexpress
TranscriptomicsCooler temperatures destabilize RNA interference and increase susceptibility of disease vector mosquitoes to viral infection
The impact of global climate change on the transmission dynamics of infectious diseases is the subject of extensive debate. The transmission of mosquito-borne viral diseases is particularly complex, with climatic variables directly affecting many parameters associated with the prevalence of disease ...
ORGANISM(S): Aedes albopictus 
2013-08-13 | E-GEOD-46204 | biostudies-arrayexpress
GenomicsRegulation of transcriptional interference by the Swi/Snf complex [nanopore]
Regulation of transcriptional interference by the Swi/Snf complex [nanopore]
PRJNA956883 | ENA
GenomicsRegulation of transcriptional interference by the Swi/Snf complex [RNA-seq]
Regulation of transcriptional interference by the Swi/Snf complex [RNA-seq]
PRJNA956077 | ENA
GenomicsRegulation of transcriptional interference by the Swi/Snf complex [Mnase-seq]
Regulation of transcriptional interference by the Swi/Snf complex [Mnase-seq]
PRJNA956071 | ENA
GenomicsRegulation of transcriptional interference by the Swi/Snf complex [ChIP-seq]
Regulation of transcriptional interference by the Swi/Snf complex [ChIP-seq]
PRJNA956070 | ENA
GenomicsRegulation of transcriptional interference by the Swi/Snf complex [TL-seq]
Regulation of transcriptional interference by the Swi/Snf complex [TL-seq]
PRJNA956074 | ENA
TranscriptomicsThe RDE-10/RDE-11 complex triggers RNAi induced mRNA degradation by association with target mRNA in C. elegans
The molecular mechanisms for target mRNA degradation in C. elegans undergoing RNA interference (RNAi) are not fully understood. Using a combination of genetic, proteomic and biochemical approaches, we report a divergent RDE-10/RDE-11 complex that is required for RNAi in C. elegans. The RDE-10/RDE-...
ORGANISM(S): Caenorhabditis elegans 
2012-04-25 | E-GEOD-36494 | biostudies-arrayexpress
ProteomicsA Triple Knockout (TKO) Proteomics Standard for Diagnosing Ion Interference in Isobaric Labeling Experiments
Isobaric labeling is a powerful strategy for quantitative mass spectrometry-based proteomic investigations. A complication of such analyses has been the co-isolation of multiple analytes of similar mass-to-charge resulting in the distortion of relative protein abundance measurements across samples. ...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2019-08-23 | MSV000084230 | MassIVE
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