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TranscriptomicsTranscription profiling of human hepatitis C virus replicon cell line treated with interferon-alpha 2a in a time series
Temporal analysis of genes regulated by Interferon-alpha 2a in a HCV (Hepatitis C Virus) Replicon Cell line
ORGANISM(S): Homo sapiens 
2011-11-08 | E-MEXP-714 | biostudies-arrayexpress
ProteomicsEndoC-betaH1 cells treated with interferon alpha
EndoC-betaH1 cells were treated with 2000 U/mL interferon alpha for 8 or 24h and submitted to proteomic analysis.
ORGANISM(S): Homo sapiens (Human) 
2020-04-15 | PXD014244 | Pride
Human Proteomics Beta cell Interferon alpha Type 1 diabetes 
TranscriptomicsIFN alpha-induced gene expression in human NK cells
NK cells are believed to contribute to the control of hepatitis C virus infection and pathogenesis of liver disease. Standard treatment of both acute and chronic hepatitis C is based on the administration of interferon alpha, however, the effects of type I interferons on human NK cells have not been...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-15743 | biostudies-arrayexpress
TranscriptomicsTranscription Profiling of Human Aortic Endothelial Cells After Treatment with Interferon-Alpha
Systemic Lupus Erythematosus is associated with an increased risk of cardiovascular disease (CVD). Interferon-response genes have been associated with endothelial dysfunction in SLE patients. The aim of this study is to identify the effects of IFN-alpha on human endothelial cells in order to deter...
ORGANISM(S): Homo sapiens 
2013-09-11 | E-MEXP-3746 | biostudies-arrayexpress
MetabolomicsPlasma Metabolome Analysis for Predicting Antiviral Treatment Efficacy in Chronic Hepatitis B: Diagnostic Biomarkers and Therapeutic Insights
The early and accurate identification of predictive biomarkers for antiviral treatment efficacy remains a significant clinical challenge, particularly in the management of chronic hepatitis B (CHB). This study aimed to assess whether the plasma metabolome could reliably predict the success of antivi...
2024-07-10 | MTBLS10401 | MetaboLights
TranscriptomicsTranscription profiling of human chromic myeloid leukemia (CML) patients treated second-line with imatinib after failure of an interferon-alpha based therapy to identify genes with predictive value for primary cytogenetic outcome to imatinib
Identification of genes in CML patients with predictive value for their primary cytogenetic outcome to imatinib. All samples analyzed were taken just before the start of imatinib treatment. Leukemic patients were treated second-line with imatinib after failure of an interferon-alpha based therapy (f...
ORGANISM(S): Homo sapiens 
2006-05-31 | E-MEXP-433 | biostudies-arrayexpress
TranscriptomicsExpression data of interferon-alpha treated Huh-7 cells
Hepatitis C virus (HCV) infection is primarily treated with a pegylated interferon alpha based therapy, a regime that induces antiviral effects through the upregulation of many interferon-stimulated genes (ISGs). Whilst a number of anti-HCV ISGs have previously been identified, others may also be in...
ORGANISM(S): Homo sapiens 
2011-11-30 | E-GEOD-34022 | biostudies-arrayexpress
TranscriptomicsComparison of the effects of early pregnancy with human interferon, alpha 2 (IFNA2) on gene expression in bovine endometrium
Interferon tau (IFNT), a Type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal, produced by the ruminant conceptus. To elucidate specific effects of bovine IFNT and of other conceptus-derived factors, endometrial gene expression changes during early pregnancy were compared to ...
ORGANISM(S): Bos taurus 
2011-10-31 | E-GEOD-30694 | biostudies-arrayexpress
TranscriptomicsExpression data from primary human dermal fibroblasts with STAT2 deficiency and control fibroblasts treated with interferon
Primary human dermal fibroblasts were isolated from an individual showing a genetic defect in innate antiviral immunity associated with profound failure of type 1 interferon signaling and absence of the STAT2 protein. The transcriptional response of these cells to a 10h treatment with interferon-alp...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-41960 | biostudies-arrayexpress
TranscriptomicsInterferon-alpha mediates the development of autoimmunity by direct tissue toxicity and through immune-cell recruitment mechanisms
Interferon-alpha is a major therapeutic agent for many diverse diseases. However, the interferon-alpha mechanism of therapeutic action and associated side effects are not well understood. In particular, thyroiditis is a common unexplained complication. We hypothesized that direct thyroid-toxic act...
ORGANISM(S): Mus musculus 
2011-11-03 | E-GEOD-25115 | biostudies-arrayexpress
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