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ProteomicsCharacterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
Despite extensive investigation, it remains a paradox that IL-2 and IL-15 can differentially modulate the immune response using the same signaling receptors. In our previous work, we dissected the phosphotyrosine-driven signaling cascades triggered by both cytokines in Kit225 T-cells unveiling subtl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080850 | MassIVE
TranscriptomicsTranscription profiling by array of rat ventricular cardiac myocytes treated with interleukin 1 beta
Study of the effects of interleukin 1 beta on transcript expression in ventricular cardiac myocytes
ORGANISM(S): Rattus norvegicus 
2010-04-01 | E-MEXP-1960 | biostudies-arrayexpress
TranscriptomicsBulk RNA sequencing of coding RNA from splenic dendritic cells isolated from interleukin-2 complex-treated and untreated mice
We discovered that interleukin-2 expands mouse dendritic cells in vivo. This RNA-seq experiment intended to identify the transcriptional changes in mouse conventional dendritic cells after interleukin-2 complex treatment and to possibly identify activated signaling pathways.
ORGANISM(S): Mus musculus 
2020-09-16 | E-MTAB-8991 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neonatal rat ventricular cardiac myocytes treated with interleukin 33 for 0.5, 1 or 2 hours
Study of the effect of interleukin 33 (IL33) on transcript expression in neonatal rat ventricular cardiac myocytes at 0.5, 1 or 2 h
ORGANISM(S): Rattus norvegicus 
2010-04-01 | E-MEXP-1912 | biostudies-arrayexpress
TranscriptomicsMacrophage-restricted Interleukin-10 receptor-, but not IL-10 deficiency causes severe spontaneous colitis
Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and sensed by most hematopoietic cells. Genome wide association studies and experimental animal models point at a central role of the IL-10 axis in Inflammatory Bowel Diseases. Here we investigated the importance of intestin...
ORGANISM(S): Mus musculus 
2014-05-09 | E-GEOD-56444 | biostudies-arrayexpress
GenomicsRegulating Interleukin-2 activity with engineered receptor signaling clamps
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. Previously, we engineered an IL-2 “superkine” (H9) with enhanced affinity for IL-2Rβ. Here, we describe next-generation IL-2 variants that...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-64713 | biostudies-arrayexpress
TranscriptomicsExpression data of macrophage phenotypes treated with interleukin-1alpha
Identification of the difference in responsiveness to interleukin-1alpha between M1 and M2 macrophage phenotypes. To identify the difference in responsiveness to interleukin-1alpha between M1 and M2 macrophage phenotypes, we performed micorarray analysis of gene expression in two phenotypes with or ...
ORGANISM(S): Mus musculus 
2014-09-21 | E-GEOD-53680 | biostudies-arrayexpress
GenomicsInterleukin-23-induced transcription factor Blimp1 promotes pathogenicity of T helper 17 cells
Interleukin-23 (IL-23) is a pro-inflammatory cytokine required for the pathogenicity of T helper 17 (Th17) cells but the molecular mechanisms governing this process remain unclear. We identified the transcription factor Blimp-1 (Prdm1) as a key IL-23-induced factor that drove the inflammatory fun...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-75724 | biostudies-arrayexpress
TranscriptomicsMechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15
Interleukin-15 (IL-15) and IL-2 possess distinct immunological functions despite both signaling through IL-2Rβ and the common cytokine receptor γ-chain, γc, We find that in the IL-15/IL-15Rα/IL-2Rβ/γc quaternary complex structure, IL-15 heterodimerizes IL-2Rβ and γc identically to the IL-2/IL-2Rα/IL...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-40350 | biostudies-arrayexpress
GenomicsAnalysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 TFs
Interleukin-21 (IL-21) is a pleiotropic cytokine that induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation and T cell homeostasis. We identified an IL-21 response element downstream of Prdm1 that binds the transcription factors STAT3 and I...
ORGANISM(S): Mus musculus 
2010-01-08 | E-GEOD-19198 | biostudies-arrayexpress
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