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TranscriptomicsMacrophage-restricted Interleukin-10 receptor-, but not IL-10 deficiency causes severe spontaneous colitis
Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and sensed by most hematopoietic cells. Genome wide association studies and experimental animal models point at a central role of the IL-10 axis in Inflammatory Bowel Diseases. Here we investigated the importance of intestin...
ORGANISM(S): Mus musculus 
2014-05-09 | E-GEOD-56444 | biostudies-arrayexpress
TranscriptomicsIMPACT OF INTERLEUKIN 10 DEFICIENCY ON INTESTINAL EPITHELIUM RESPONSES TO INFLAMMATORY SIGNALS
Interleukin-10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has a major protective role in the intestine. Although its production by cells of the innate and adaptive immune system have been extensively studied, its intrinsic role in intestinal epithelial cells is poorly understood. In t...
ORGANISM(S): Mus musculus 
2021-12-30 | E-MTAB-10217 | biostudies-arrayexpress
TranscriptomicsProtective Role of IL-10 in Ozone-induced Pulmonary Inflammation
Background: The mechanisms underlying ozone (O3)-induced pulmonary inflammation remain unclear. Interleukin (IL)-10 is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators. Objectives: The current study investigated the molecular mechanisms underlying IL-10-mediated attenua...
ORGANISM(S): Mus musculus 
2011-10-18 | E-GEOD-25095 | biostudies-arrayexpress
MetabolomicsFunctional Remodeling of iNKT Cells by Sulfatide-Reactive Type II NKT Cells Reprograms Alveolar Macrophages to Alleviate Lung Ischemia-Reperfusion Injury

Lung ischemia-reperfusion injury (LIRI) is a serious complication in critical clinical situations. Despite its importance, the specific role of type II natural killer T (NKT) cells in LIRI remains unclear. In this study, we establish a LIRI mouse model and demonstrate that sulfatide-reactive type...

2025-12-19 | MTBLS13533 | MetaboLights
GenomicsEffect of interleukin-10 on primary oligodendrocyte progenitor cells under hemin administration
Effect of interleukin-10 on primary oligodendrocyte progenitor cells under hemin administration
PRJNA917509 | ENA
GenomicsColonic transcriptomic data of interleukin-10-deficient mice
Colonic transcriptomic data of interleukin-10-deficient mice
PRJNA1101898 | ENA
GenomicsMacrophage-based delivery of interleukin-10 alleviates atherosclerosis
Macrophage-based delivery of interleukin-10 alleviates atherosclerosis
PRJNA1046023 | ENA
TranscriptomicsInterleukin-10-anergized T-cell infusion provides immune reconstitution without severe graft-versus-host disease after haploidentical hematopoietic stem cell transplantation
Regulatory T cells restore tolerance in preclinical models of immune-mediated diseases and are therefore a promising alternative to conventional immune-suppression for preventing graft-versus-host disease (GvHD) in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). Adaptiv...
ORGANISM(S): Homo sapiens 
2015-12-14 | E-GEOD-21885 | biostudies-arrayexpress
TranscriptomicsExogenous Interleukin-10 versus Glucocorticoids: Effect on Gene Expression and Pro-inflammatory Cytokine Release in Polymorphonuclear Leukocytes and Monocytes of the Newborn
INTRODUCTION: Persistent lung inflammation, with an influx of polymorphonuclear leukocytes and monocytes, occurs early in bronchopulmonary dysplasia. We hypothesized that: 1) that interleukin-10, a potent anti-inflammatory cytokine, would cause a markedly different gene expression profile compared t...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-35683 | biostudies-arrayexpress
GenomicsStudying the exome of e46 interleukin 10 mutant zebrafish (Danio rerio)
Studying the exome of e46 interleukin 10 mutant zebrafish (Danio rerio)
PRJEB27234 | ENA
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